Irreversibility of cellular senescence: dual roles of p16INK4a/Rb-pathway in cell cycle control

by Takahashi, Akiko, Ohtani, Naoko, Hara, Eiji
Published 2007

Reduction of total E2F/DP activity induces senescence-like cell cycle arrest in cancer cells lacking functional pRB and p53

by Maehara, Kayoko, Yamakoshi, Kimi, Ohtani, Naoko, Kubo, Yoshiaki, Takahashi, Akiko, Arase, Seiji, Jones, Nic, Hara, Eiji
Published 2005

E2FBP1 antagonizes the p16INK4A-Rb tumor suppressor machinery for growth suppression and cellular senescence by regulating promyelocytic leukemia protein stability

by Fukuyo, Yayoi, Takahashi, Akiko, Hara, Eiji, Horikoshi, Nobuo, Pandita, Tej K, Nakajima, Takuma
Published 2011

Evidence for a CDK4-dependent checkpoint in a conditional model of cellular senescence

by Brookes, Sharon, Gagrica, Sladjana, Sanij, Elaine, Rowe, Janice, Gregory, Fiona J, Hara, Eiji, Peters, Gordon
Published 2015

Epstein-Barr virus LMP1 blocks p16INK4a–RB pathway by promoting nuclear export of E2F4/5

by Ohtani, Naoko, Brennan, Paul, Gaubatz, Stefan, Sanij, Elaine, Hertzog, Paul, Wolvetang, Ernst, Ghysdael, Jacques, Rowe, Martin, Hara, Eiji
Published 2003

Dysregulation of the Bmi-1/p16Ink4a pathway provokes an aging-associated decline of submandibular gland function

by Yamakoshi, Kimi, Katano, Satoshi, Iida, Mayu, Kimura, Hiromi, Okuma, Atsushi, Ikemoto-Uezumi, Madoka, Ohtani, Naoko, Hara, Eiji, Maruyama, Mitsuo
Published 2015

In vivo imaging models of bone and brain metastases and pleural carcinomatosis with a novel human EML4-ALK lung cancer cell line

by Nanjo, Shigeki, Nakagawa, Takayuki, Takeuchi, Shinji, Kita, Kenji, Fukuda, Koji, Nakada, Mitsutoshi, Uehara, Hisanori, Nishihara, Hiroshi, Hara, Eiji, Uramoto, Hidetaka, Tanaka, Fumihiro, Yano, Seiji
Published 2015

Real-time in vivo imaging of p16Ink4a reveals cross talk with p53

by Yamakoshi, Kimi, Takahashi, Akiko, Hirota, Fumiko, Nakayama, Rika, Ishimaru, Naozumi, Kubo, Yoshiaki, Mann, David J., Ohmura, Masako, Hirao, Atsushi, Saya, Hideyuki, Arase, Seiji, Hayashi, Yoshio, Nakao, Kazuki, Matsumoto, Mitsuru, Ohtani, Naoko, Hara, Eiji
Published 2009

Ablation of the p16INK4a tumour suppressor reverses ageing phenotypes of klotho mice

by Sato, Seidai, Kawamata, Yuka, Takahashi, Akiko, Imai, Yoshinori, Hanyu, Aki, Okuma, Atsushi, Takasugi, Masaki, Yamakoshi, Kimi, Sorimachi, Hiroyuki, Kanda, Hiroaki, Ishikawa, Yuichi, Sone, Saburo, Nishioka, Yasuhiko, Ohtani, Naoko, Hara, Eiji
Published 2015