Irreversibility of cellular senescence: dual roles of p16INK4a/Rb-pathway in cell cycle control
The retinoblastoma (Rb) tumor suppressor gene product, pRb, has an established role in the implementation of cellular senescence, the state of irreversible G1 cell cycle arrest provoked by diverse oncogenic stresses. In murine cells, senescence cell cycle arrest can be reversed by subsequent inactiv...
| Main Authors: | , , |
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| Format: | Online |
| Language: | English |
| Published: |
BioMed Central
2007
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1838411/ |