Chemical, genetic and structural assessment of pyridoxal kinase as a drug target in the African trypanosome
Pyridoxal-5′-phosphate (vitamin B6) is an essential cofactor for many important enzymatic reactions such as transamination and decarboxylation. African trypanosomes are unable to synthesise vitamin B6de novo and rely on uptake of B6 vitamers such as pyridoxal and pyridoxamine from their hosts, which...
| Main Authors: | , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Blackwell Publishing Ltd
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3470933/ |