Prevention of 5-hydroxytryptamine2C receptor RNA editing and alternate splicing in C57BL/6 mice activates the hypothalamic-pituitary-adrenal axis and alters mood

by Bombail, Vincent, Qing, Wei, Chapman, Karen E, Holmes, Megan C
Published 2014

Modulation of 11β-Hydroxysteroid Dehydrogenase as a Strategy to Reduce Vascular Inflammation

by Hadoke, Patrick W. F., Kipari, Tiina, Seckl, Jonathan R., Chapman, Karen E.
Published 2013

Changing glucocorticoid action: 11β-Hydroxysteroid dehydrogenase type 1 in acute and chronic inflammation

by Chapman, Karen E., Coutinho, Agnes E., Zhang, Zhenguang, Kipari, Tiina, Savill, John S., Seckl, Jonathan R.
Published 2013

A novel role for the mineralocorticoid receptor in glucocorticoid driven vascular calcification

by Zhu, Dongxing, Rashdan, Nabil A., Chapman, Karen E., Hadoke, Patrick WF, MacRae, Vicky E.
Published 2016

Peripheral mechanisms contributing to the glucocorticoid hypersensitivity in proopiomelanocortin null mice treated with corticosterone

by Michailidou, Zoi, Coll, Anthony P, Kenyon, Christopher J, Morton, Nicholas M, O'Rahilly, Stephen, Seckl, Jonathan R, Chapman, Karen E
Published 2007

Stable conditional expression and effect of C/EBPβ-LIP in adipocytes using the pSLIK system

by Esteves, Cristina L, Kelly, Val, Bégay, Valérie, Lillico, Simon G, Leutz, Achim, Seckl, Jonathan R, Chapman, Karen E
Published 2013

11β-hydroxysteroid dehydrogenase-1 deficiency alters the gut microbiome response to Western diet

by Johnson, Jethro S, Opiyo, Monica N, Thomson, Marian, Gharbi, Karim, Seckl, Jonathan R, Heger, Andreas, Chapman, Karen E
Published 2016

Getting to the heart of intracellular glucocorticoid regeneration: 11β-HSD1 in the myocardium

by Gray, Gillian A, White, Christopher I, Castellan, Raphael F P, McSweeney, Sara J, Chapman, Karen E
Published 2016

11β-Hydroxysteroid Dehydrogenase Type 1, But Not Type 2, Deficiency Worsens Acute Inflammation and Experimental Arthritis in Mice

by Coutinho, Agnes E., Gray, Mohini, Brownstein, David G., Salter, Donald M., Sawatzky, Deborah A., Clay, Spike, Gilmour, James S., Seckl, Jonathan R., Savill, John S., Chapman, Karen E.
Published 2012

Regulation of Adipocyte 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) by CCAAT/Enhancer-Binding Protein (C/EBP) β Isoforms, LIP and LAP

by Esteves, Cristina L., Kelly, Val, Bégay, Valérie, Man, Tak Y., Morton, Nicholas M., Leutz, Achim, Seckl, Jonathan R., Chapman, Karen E.
Published 2012

Salicylate Downregulates 11β-HSD1 Expression in Adipose Tissue in Obese Mice and in Humans, Mediating Insulin Sensitization

by Nixon, Mark, Wake, Deborah J., Livingstone, Dawn E., Stimson, Roland H., Esteves, Cristina L., Seckl, Jonathan R., Chapman, Karen E., Andrew, Ruth, Walker, Brian R.
Published 2012

Pro-Inflammatory Cytokine Induction of 11β-hydroxysteroid Dehydrogenase Type 1 in A549 Cells Requires Phosphorylation of C/EBPβ at Thr235

by Esteves, Cristina L., Verma, Manu, Róg-Zielińska, Ewa, Kelly, Val, Sai, Shuji, Breton, Amandine, Donadeu, Francesc X., Seckl, Jonathan R., Chapman, Karen E.
Published 2013

Mast Cells Express 11β-hydroxysteroid Dehydrogenase Type 1: A Role in Restraining Mast Cell Degranulation

by Coutinho, Agnes E., Brown, Jeremy K., Yang, Fu, Brownstein, David G., Gray, Mohini, Seckl, Jonathan R., Savill, John S., Chapman, Karen E.
Published 2013

Lung epithelial tip progenitors integrate glucocorticoid- and STAT3-mediated signals to control progeny fate

by Laresgoiti, Usua, Nikolić, Marko Z., Rao, Chandrika, Brady, Jane L., Richardson, Rachel V., Batchen, Emma J., Chapman, Karen E., Rawlins, Emma L.
Published 2016

Novel Fat Depot–Specific Mechanisms Underlie Resistance to Visceral Obesity and Inflammation in 11β-Hydroxysteroid Dehydrogenase Type 1–Deficient Mice

by Wamil, Malgorzata, Battle, Jenny H., Turban, Sophie, Kipari, Tiina, Seguret, David, de Sousa Peixoto, Ricardo, Nelson, Yvonne B., Nowakowska, Dominika, Ferenbach, David, Ramage, Lynne, Chapman, Karen E., Hughes, Jeremy, Dunbar, Donald R., Seckl, Jonathan R., Morton, Nicholas M.
Published 2011

Cardiomyocyte and Vascular Smooth Muscle-Independent 11β-Hydroxysteroid Dehydrogenase 1 Amplifies Infarct Expansion, Hypertrophy, and the Development of Heart Failure After Myocard...

by White, Christopher I., Jansen, Maurits A., McGregor, Kieran, Mylonas, Katie J., Richardson, Rachel V., Thomson, Adrian, Moran, Carmel M., Seckl, Jonathan R., Walker, Brian R., Chapman, Karen E., Gray, Gillian A.
Published 2016

11β-Hydroxysteroid Dehydrogenase Type 1 Is Expressed in Neutrophils and Restrains an Inflammatory Response in Male Mice

by Coutinho, Agnes E., Kipari, Tiina M. J., Zhang, Zhenguang, Esteves, Cristina L., Lucas, Christopher D., Gilmour, James S., Webster, Scott P., Walker, Brian R., Hughes, Jeremy, Savill, John S., Seckl, Jonathan R., Rossi, Adriano G., Chapman, Karen E.
Published 2016

11β-hydroxysteroid dehydrogenase type 1 deficiency in bone marrow-derived cells reduces atherosclerosis

by Kipari, Tiina, Hadoke, Patrick W. F., Iqbal, Javaid, Man, Tak-Yung, Miller, Eileen, Coutinho, Agnes E., Zhang, Zhenguang, Sullivan, Katie M., Mitic, Tijana, Livingstone, Dawn E. W., Schrecker, Christopher, Samuel, Kay, White, Christopher I., Bouhlel, M. Amine, Chinetti-Gbaguidi, Giulia, Staels, Bart, Andrew, Ruth, Walker, Brian R., Savill, John S., Chapman, Karen E., Seckl, Jonathan R.
Published 2013

Increased Skeletal Muscle 11βHSD1 mRNA Is Associated with Lower Muscle Strength in Ageing

by Kilgour, Alixe H. M., Gallagher, Iain J., MacLullich, Alasdair M. J., Andrew, Ruth, Gray, Calum D., Hyde, Philippa, Wackerhage, Henning, Husi, Holger, Ross, James A., Starr, John M., Chapman, Karen E., Fearon, Kenneth C. H., Walker, Brian R., Greig, Carolyn A.
Published 2013