11β-hydroxysteroid dehydrogenase-1 deficiency alters the gut microbiome response to Western diet

11β-hydroxysteroid dehydrogenase-1 deficiency alters the gut microbiome response to Western diet

The enzyme 11β-hydroxysteroid dehydrogenase (11β-HSD) interconverts active glucocorticoids and their intrinsically inert 11-keto forms. The type 1 isozyme, 11β-HSD1, predominantly reactivates glucocorticoids in vivo and can also metabolise bile acids. 11β-HSD1-deficient mice show altered inflammator...

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Bibliographic Details
Main Authors: Johnson, Jethro S, Opiyo, Monica N, Thomson, Marian, Gharbi, Karim, Seckl, Jonathan R, Heger, Andreas, Chapman, Karen E
Format: Online
Language:English
Published: Bioscientifica Ltd 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5184774/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5184774/

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