Next-Generation Sequencing in Post-mortem Genetic Testing of Young Sudden Cardiac Death Cases

by Lahrouchi, Najim, Behr, Elijah R., Bezzina, Connie R.
Published 2016

Induced pluripotent stem cell derived cardiomyocytes as models for cardiac arrhythmias

by Hoekstra, Maaike, Mummery, Christine L., Wilde, Arthur A. M., Bezzina, Connie R., Verkerk, Arie O.
Published 2012

SNPs Identified as Modulators of ECG Traits in the General Population Do Not Markedly Affect ECG Traits during Acute Myocardial Infarction nor Ventricular Fibrillation Risk in This...

by Pazoki, Raha, de Jong, Jonas S.S.G., Marsman, Roos F., Bruinsma, Nienke, Dekker, Lukas R. C., Wilde, Arthur A. M., Bezzina, Connie R., Tanck, Michael W. T.
Published 2013

A Heterozygous Deletion Mutation in the Cardiac Sodium Channel Gene SCN5A with Loss- and Gain-of-Function Characteristics Manifests as Isolated Conduction Disease, without Signs of...

by Zumhagen, Sven, Veldkamp, Marieke W., Stallmeyer, Birgit, Baartscheer, Antonius, Eckardt, Lars, Paul, Matthias, Remme, Carol Ann, Bhuiyan, Zahurul A., Bezzina, Connie R., Schulze-Bahr, Eric
Published 2013

hiPSC-derived cardiomyocytes from Brugada Syndrome patients without identified mutations do not exhibit clear cellular electrophysiological abnormalities

by Veerman, Christiaan C., Mengarelli, Isabella, Guan, Kaomei, Stauske, Michael, Barc, Julien, Tan, Hanno L., Wilde, Arthur A. M., Verkerk, Arie O., Bezzina, Connie R.
Published 2016

Dissection of a Quantitative Trait Locus for PR Interval Duration Identifies Tnni3k as a Novel Modulator of Cardiac Conduction

by Lodder, Elisabeth M., Scicluna, Brendon P., Milano, Annalisa, Sun, Albert Y., Tang, Hao, Remme, Carol Ann, Moerland, Perry D., Tanck, Michael W. T., Pitt, Geoffrey S., Marchuk, Douglas A., Bezzina, Connie R.
Published 2012

Genome-Wide Identification of Expression Quantitative Trait Loci (eQTLs) in Human Heart

by Koopmann, Tamara T., Adriaens, Michiel E., Moerland, Perry D., Marsman, Roos F., Westerveld, Margriet L., Lal, Sean, Zhang, Taifang, Simmons, Christine Q., Baczko, Istvan, dos Remedios, Cristobal, Bishopric, Nanette H., Varro, Andras, George, Alfred L., Lodder, Elisabeth M., Bezzina, Connie R.
Published 2014

Myocyte necrosis underlies progressive myocardial dystrophy in mouse dsg2-related arrhythmogenic right ventricular cardiomyopathy

by Pilichou, Kalliopi, Remme, Carol Ann, Basso, Cristina, Campian, Maria E., Rizzo, Stefania, Barnett, Phil, Scicluna, Brendon P., Bauce, Barbara, van den Hoff, Maurice J.B., de Bakker, Jacques M.T., Tan, Hanno L., Valente, Marialuisa, Nava, Andrea, Wilde, Arthur A.M., Moorman, Antoon F.M., Thiene, Gaetano, Bezzina, Connie R.
Published 2009

Variants in the 3′ untranslated region of the KCNQ1-encoded Kv7.1 potassium channel modify disease severity in patients with type 1 long QT syndrome in an allele-specific manner

by Amin, Ahmad S., Giudicessi, John R., Tijsen, Anke J., Spanjaart, Anne M., Reckman, Yolan J., Klemens, Christine A., Tanck, Michael W., Kapplinger, Jamie D., Hofman, Nynke, Sinner, Moritz F., Müller, Martina, Wijnen, Wino J., Tan, Hanno L., Bezzina, Connie R., Creemers, Esther E., Wilde, Arthur A. M., Ackerman, Michael J., Pinto, Yigal M.
Published 2012

Variants in the SCN5A Promoter Associated With Various Arrhythmia Phenotypes

by Yagihara, Nobue, Watanabe, Hiroshi, Barnett, Phil, Duboscq‐Bidot, Laetitia, Thomas, Atack C., Yang, Ping, Ohno, Seiko, Hasegawa, Kanae, Kuwano, Ryozo, Chatel, Stéphanie, Redon, Richard, Schott, Jean‐Jacques, Probst, Vincent, Koopmann, Tamara T., Bezzina, Connie R., Wilde, Arthur A. M., Nakano, Yukiko, Aiba, Takeshi, Miyamoto, Yoshihiro, Kamakura, Shiro, Darbar, Dawood, Donahue, Brian S., Shigemizu, Daichi, Tanaka, Toshihiro, Tsunoda, Tatsuhiko, Suda, Masayoshi, Sato, Akinori, Minamino, Tohru, Endo, Naoto, Shimizu, Wataru, Horie, Minoru, Roden, Dan M., Makita, Naomasa
Published 2016

Genome Wide Analysis of Drug-Induced Torsades de Pointes: Lack of Common Variants with Large Effect Sizes

by Behr, Elijah R., Ritchie, Marylyn D., Tanaka, Toshihiro, Kääb, Stefan, Crawford, Dana C., Nicoletti, Paola, Floratos, Aris, Sinner, Moritz F., Kannankeril, Prince J., Wilde, Arthur A. M., Bezzina, Connie R., Schulze-Bahr, Eric, Zumhagen, Sven, Guicheney, Pascale, Bishopric, Nanette H., Marshall, Vanessa, Shakir, Saad, Dalageorgou, Chrysoula, Bevan, Steve, Jamshidi, Yalda, Bastiaenen, Rachel, Myerburg, Robert J., Schott, Jean-Jacques, Camm, A. John, Steinbeck, Gerhard, Norris, Kris, Altman, Russ B., Tatonetti, Nicholas P., Jeffery, Steve, Kubo, Michiaki, Nakamura, Yusuke, Shen, Yufeng, George, Alfred L., Roden, Dan M.
Published 2013

Genome-wide association study of multiple congenital heart disease phenotypes identifies a susceptibility locus for atrial septal defect at chromosome 4p16

by Cordell, Heather J., Bentham, Jamie, Topf, Ana, Zelenika, Diana, Heath, Simon, Mamasoula, Chrysovalanto, Cosgrove, Catherine, Blue, Gillian, Granados-Riveron, Javier, Setchfield, Kerry, Thornborough, Chris, Breckpot, Jeroen, Soemedi, Rachel, Martin, Ruairidh, Rahman, Thahira J., Hall, Darroch, van Engelen, Klaartje, Moorman, Antoon F.M., Zwinderman, Aelko H, Barnett, Phil, Koopmann, Tamara T., Adriaens, Michiel E., Varro, Andras, George, Alfred L., dos Remedios, Christobal, Bishopric, Nanette H., Bezzina, Connie R., O’Sullivan, John, Gewillig, Marc, Bu’Lock, Frances A., Winlaw, David, Bhattacharya, Shoumo, Devriendt, Koen, Brook, J. David, Mulder, Barbara J.M., Mital, Seema, Postma, Alex V., Lathrop, G. Mark, Farrall, Martin, Goodship, Judith A., Keavney, Bernard D.
Published 2013

Genome-wide association of multiple complex traits in outbred mice by ultra low-coverage sequencing

by Nicod, Jérôme, Davies, Robert W., Cai, Na, Hassett, Carl, Goodstadt, Leo, Cosgrove, Cormac, Yee, Benjamin K, Lionikaite, Vikte, McIntyre, Rebecca E, Remme, Carol Ann, Lodder, Elisabeth M., Gregory, Jennifer S., Hough, Tertius, Joynson, Russell, Phelps, Hayley, Nell, Barbara, Rowe, Clare, Wood, Joe, Walling, Alison, Bopp, Nasrin, Bhomra, Amarjit, Hernandez-Pliego, Polinka, Callebert, Jacques, Aspden, Richard M., Talbot, Nick P, Robbins, Peter A, Harrison, Mark, Fray, Martin, Launay, Jean-Marie, Pinto, Yigal M., Blizard, David A., Bezzina, Connie R., Adams, David J, Franken, Paul, Weaver, Tom, Wells, Sara, Brown, Steve DM, Potter, Paul K, Klenerman, Paul, Lionikas, Arimantas, Mott, Richard, Flint, Jonathan
Published 2016

Identification of a Sudden Cardiac Death Susceptibility Locus at 2q24.2 through Genome-Wide Association in European Ancestry Individuals

by Arking, Dan E., Junttila, M. Juhani, Goyette, Philippe, Huertas-Vazquez, Adriana, Eijgelsheim, Mark, Blom, Marieke T., Newton-Cheh, Christopher, Reinier, Kyndaron, Teodorescu, Carmen, Uy-Evanado, Audrey, Carter-Monroe, Naima, Kaikkonen, Kari S., Kortelainen, Marja-Leena, Boucher, Gabrielle, Lagacé, Caroline, Moes, Anna, Zhao, XiaoQing, Kolodgie, Frank, Rivadeneira, Fernando, Hofman, Albert, Witteman, Jacqueline C. M., Uitterlinden, André G., Marsman, Roos F., Pazoki, Raha, Bardai, Abdennasser, Koster, Rudolph W., Dehghan, Abbas, Hwang, Shih-Jen, Bhatnagar, Pallav, Post, Wendy, Hilton, Gina, Prineas, Ronald J., Li, Man, Köttgen, Anna, Ehret, Georg, Boerwinkle, Eric, Coresh, Josef, Kao, W. H. Linda, Psaty, Bruce M., Tomaselli, Gordon F., Sotoodehnia, Nona, Siscovick, David S., Burke, Greg L., Marbán, Eduardo, Spooner, Peter M., Cupples, L. Adrienne, Jui, Jonathan, Gunson, Karen, Kesäniemi, Y. Antero, Wilde, Arthur A. M., Tardif, Jean-Claude, O'Donnell, Christopher J., Bezzina, Connie R., Virmani, Renu, Stricker, Bruno H. C. h., Tan, Hanno L., Albert, Christine M., Chakravarti, Aravinda, Rioux, John D., Huikuri, Heikki V., Chugh, Sumeet S.
Published 2011

Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization

by Arking, Dan E., Pulit, Sara L., Crotti, Lia, van der Harst, Pim, Munroe, Patricia B., Koopmann, Tamara T., Sotoodehnia, Nona, Rossin, Elizabeth J., Morley, Michael, Wang, Xinchen, Johnson, Andrew D., Lundby, Alicia, Gudbjartsson, Daníel F., Noseworthy, Peter A., Eijgelsheim, Mark, Bradford, Yuki, Tarasov, Kirill V., Dörr, Marcus, Müller-Nurasyid, Martina, Lahtinen, Annukka M., Nolte, Ilja M., Smith, Albert Vernon, Bis, Joshua C., Isaacs, Aaron, Newhouse, Stephen J., Evans, Daniel S., Post, Wendy S., Waggott, Daryl, Lyytikäinen, Leo-Pekka, Hicks, Andrew A., Eisele, Lewin, Ellinghaus, David, Hayward, Caroline, Navarro, Pau, Ulivi, Sheila, Tanaka, Toshiko, Tester, David J., Chatel, Stéphanie, Gustafsson, Stefan, Kumari, Meena, Morris, Richard W., Naluai, Åsa T., Padmanabhan, Sandosh, Kluttig, Alexander, Strohmer, Bernhard, Panayiotou, Andrie G., Torres, Maria, Knoflach, Michael, Hubacek, Jaroslav A., Slowikowski, Kamil, Raychaudhuri, Soumya, Kumar, Runjun D., Harris, Tamara B., Launer, Lenore J., Shuldiner, Alan R., Alonso, Alvaro, Bader, Joel S., Ehret, Georg, Huang, Hailiang, Kao, W.H. Linda, Strait, James B., Macfarlane, Peter W., Brown, Morris, Caulfield, Mark J., Samani, Nilesh J., Kronenberg, Florian, Willeit, Johann, Smith, J. Gustav, Greiser, Karin H., zu Schwabedissen, Henriette Meyer, Werdan, Karl, Carella, Massimo, Zelante, Leopoldo, Heckbert, Susan R., Psaty, Bruce M., Rotter, Jerome I., Kolcic, Ivana, Polašek, Ozren, Wright, Alan F., Griffin, Maura, Daly, Mark J., Arnar, David O., Hólm, Hilma, Thorsteinsdottir, Unnur, Denny, Joshua C., Roden, Dan M., Zuvich, Rebecca L., Emilsson, Valur, Plump, Andrew S., Larson, Martin G., O'Donnell, Christopher J., Yin, Xiaoyan, Bobbo, Marco, D'Adamo, Adamo P., Iorio, Annamaria, Sinagra, Gianfranco, Carracedo, Angel, Cummings, Steven R., Nalls, Michael A., Jula, Antti, Kontula, Kimmo K., Marjamaa, Annukka, Oikarinen, Lasse, Perola, Markus, Porthan, Kimmo, Erbel, Raimund, Hoffmann, Per, Jöckel, Karl-Heinz, Kälsch, Hagen, Nöthen, Markus M., consortium, HRGEN, den Hoed, Marcel, Loos, Ruth J.F., Thelle, Dag S., Gieger, Christian, Meitinger, Thomas, Perz, Siegfried, Peters, Annette, Prucha, Hanna, Sinner, Moritz F., Waldenberger, Melanie, de Boer, Rudolf A., Franke, Lude, van der Vleuten, Pieter A., Beckmann, Britt Maria, Martens, Eimo, Bardai, Abdennasser, Hofman, Nynke, Wilde, Arthur A.M., Behr, Elijah R., Dalageorgou, Chrysoula, Giudicessi, John R., Medeiros-Domingo, Argelia, Barc, Julien, Kyndt, Florence, Probst, Vincent, Ghidoni, Alice, Insolia, Roberto, Hamilton, Robert M., Scherer, Stephen W., Brandimarto, Jeffrey, Margulies, Kenneth, Moravec, Christine E., Fabiola Del, Greco M., Fuchsberger, Christian, O'Connell, Jeffrey R., Lee, Wai K., Watt, Graham C.M., Campbell, Harry, Wild, Sarah H., El Mokhtari, Nour E., Frey, Norbert, Asselbergs, Folkert W., Leach, Irene Mateo, Navis, Gerjan, van den Berg, Maarten P., van Veldhuisen, Dirk J., Kellis, Manolis, Krijthe, Bouwe P., Franco, Oscar H., Hofman, Albert, Kors, Jan A., Uitterlinden, André G., Witteman, Jacqueline C.M., Kedenko, Lyudmyla, Lamina, Claudia, Oostra, Ben A., Abecasis, Gonçalo R., Lakatta, Edward G., Mulas, Antonella, Orrú, Marco, Schlessinger, David, Uda, Manuela, Markus, Marcello R.P., Völker, Uwe, Snieder, Harold, Spector, Timothy D., Ärnlöv, Johan, Lind, Lars, Sundström, Johan, Syvänen, Ann-Christine, Kivimaki, Mika, Kähönen, Mika, Mononen, Nina, Raitakari, Olli T., Viikari, Jorma S., Adamkova, Vera, Kiechl, Stefan, Brion, Maria, Nicolaides, Andrew N., Paulweber, Bernhard, Haerting, Johannes, Dominiczak, Anna F., Nyberg, Fredrik, Whincup, Peter H., Hingorani, Aroon, Schott, Jean-Jacques, Bezzina, Connie R., Ingelsson, Erik, Ferrucci, Luigi, Gasparini, Paolo, Wilson, James F., Rudan, Igor, Franke, Andre, Mühleisen, Thomas W., Pramstaller, Peter P., Lehtimäki, Terho J., Paterson, Andrew D., Parsa, Afshin, Liu, Yongmei, van Duijn, Cornelia, Siscovick, David S., Gudnason, Vilmundur, Jamshidi, Yalda, Salomaa, Veikko, Felix, Stephan B., Sanna, Serena, Ritchie, Marylyn D., Stricker, Bruno H., Stefansson, Kari, Boyer, Laurie A., Cappola, Thomas P., Olsen, Jesper V., Lage, Kasper, Schwartz, Peter J., Kääb, Stefan, Chakravarti, Aravinda, Ackerman, Michael J., Pfeufer, Arne, de Bakker, Paul I.W., Newton-Cheh, Christopher
Published 2014