Genome Wide Analysis of Drug-Induced Torsades de Pointes: Lack of Common Variants with Large Effect Sizes

Genome Wide Analysis of Drug-Induced Torsades de Pointes: Lack of Common Variants with Large Effect Sizes

Marked prolongation of the QT interval on the electrocardiogram associated with the polymorphic ventricular tachycardia Torsades de Pointes is a serious adverse event during treatment with antiarrhythmic drugs and other culprit medications, and is a common cause for drug relabeling and withdrawal. A...

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Main Authors: Behr, Elijah R., Ritchie, Marylyn D., Tanaka, Toshihiro, Kääb, Stefan, Crawford, Dana C., Nicoletti, Paola, Floratos, Aris, Sinner, Moritz F., Kannankeril, Prince J., Wilde, Arthur A. M., Bezzina, Connie R., Schulze-Bahr, Eric, Zumhagen, Sven, Guicheney, Pascale, Bishopric, Nanette H., Marshall, Vanessa, Shakir, Saad, Dalageorgou, Chrysoula, Bevan, Steve, Jamshidi, Yalda, Bastiaenen, Rachel, Myerburg, Robert J., Schott, Jean-Jacques, Camm, A. John, Steinbeck, Gerhard, Norris, Kris, Altman, Russ B., Tatonetti, Nicholas P., Jeffery, Steve, Kubo, Michiaki, Nakamura, Yusuke, Shen, Yufeng, George, Alfred L., Roden, Dan M.
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3819377/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3819377/

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