Optic Atrophy 1 Is Epistatic to the Core MICOS Component MIC60 in Mitochondrial Cristae Shape Control

Optic Atrophy 1 Is Epistatic to the Core MICOS Component MIC60 in Mitochondrial Cristae Shape Control

The mitochondrial contact site and cristae organizing system (MICOS) and Optic atrophy 1 (OPA1) control cristae shape, thus affecting mitochondrial function and apoptosis. Whether and how they physically and functionally interact is unclear. Here, we provide evidence that OPA1 is epistatic to MICOS...

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Bibliographic Details
Main Authors: Glytsou, Christina, Calvo, Enrique, Cogliati, Sara, Mehrotra, Arpit, Anastasia, Irene, Rigoni, Giovanni, Raimondi, Andrea, Shintani, Norihito, Loureiro, Marta, Vazquez, Jesùs, Pellegrini, Luca, Enriquez, Jose Antonio, Scorrano, Luca, Soriano, Maria Eugenia
Format: Online
Language:English
Published: Cell Press 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5186903/

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