E3 Ligase SCFβTrCP-induced DYRK1A Protein Degradation Is Essential for Cell Cycle Progression in HEK293 Cells*
DYRK1A, located on the Down syndrome (DS) critical region of chromosome 21, was found to be overexpressed in brains of DS and Alzheimer's disease individuals. DYRK1A was considered to play important roles in the pathogenesis of DS and Alzheimer's disease; however, the degradation mechanism...
| Main Authors: | , , , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
American Society for Biochemistry and Molecular Biology
2016
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5159501/ |