HIV-1 Vpu Neutralizes the Antiviral Factor Tetherin/BST-2 by Binding It and Directing Its Beta-TrCP2-Dependent Degradation

HIV-1 Vpu Neutralizes the Antiviral Factor Tetherin/BST-2 by Binding It and Directing Its Beta-TrCP2-Dependent Degradation

Host cells impose a broad range of obstacles to the replication of retroviruses. Tetherin (also known as CD317, BST-2 or HM1.24) impedes viral release by retaining newly budded HIV-1 virions on the surface of cells. HIV-1 Vpu efficiently counteracts this restriction. Here, we show that HIV-1 Vpu ind...

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Bibliographic Details
Main Authors: Mangeat, Bastien, Gers-Huber, Gustavo, Lehmann, Martin, Zufferey, Madeleine, Luban, Jeremy, Piguet, Vincent
Format: Online
Language:English
Published: Public Library of Science 2009
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2729927/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2729927/

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