Erioflorin Stabilizes the Tumor Suppressor Pdcd4 by Inhibiting Its Interaction with the E3-ligase β-TrCP1

Erioflorin Stabilizes the Tumor Suppressor Pdcd4 by Inhibiting Its Interaction with the E3-ligase β-TrCP1

Loss of the tumor suppressor Pdcd4 was reported for various tumor entities and proposed as a prognostic marker in tumorigenesis. We previously characterized decreased Pdcd4 protein stability in response to mitogenic stimuli, which resulted from p70S6K1-dependent protein phosphorylation, β-TrCP1-medi...

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Bibliographic Details
Main Authors: Blees, Johanna S., Bokesch, Heidi R., Rübsamen, Daniela, Schulz, Kathrin, Milke, Larissa, Bajer, Magdalena M., Gustafson, Kirk R., Henrich, Curtis J., McMahon, James B., Colburn, Nancy H., Schmid, Tobias, Brüne, Bernhard
Format: Online
Language:English
Published: Public Library of Science 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3462793/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3462793/

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