Myeloid DLL4 Does Not Contribute to the Pathogenesis of Non-Alcoholic Steatohepatitis in Ldlr-/- Mice

Myeloid DLL4 Does Not Contribute to the Pathogenesis of Non-Alcoholic Steatohepatitis in Ldlr-/- Mice

Non-alcoholic steatohepatitis (NASH) is characterized by liver steatosis and inflammation. Currently, the underlying mechanisms leading to hepatic inflammation are not fully understood and consequently, therapeutic options are poor. Non-alcoholic steatohepatitis (NASH) and atherosclerosis share the...

Full description

Bibliographic Details
Main Authors:	Jeurissen, Mike L. J., Walenbergh, Sofie M. A., Houben, Tom, Hendrikx, Tim, Li, Jieyi, Oligschlaeger, Yvonne, van Gorp, Patrick J., Gijbels, Marion J. J., Bitorina, Albert, Nessel, Isabell, Radtke, Freddy, Vooijs, Marc, Theys, Jan, Shiri-Sverdlov, Ronit
Format:	Online
Language:	English
Published:	Public Library of Science 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127569/

Similar Items

MSP is a negative regulator of inflammation and lipogenesis in ex vivo models of non-alcoholic steatohepatitis
by: Chanda, Dipanjan, et al.
Published: (2016)

Macrophage Stimulating Protein Enhances Hepatic Inflammation in a NASH Model
by: Li, Jieyi, et al.
Published: (2016)

Weekly Treatment of 2-Hydroxypropyl-β-cyclodextrin Improves Intracellular Cholesterol Levels in LDL Receptor Knockout Mice
by: Walenbergh, Sofie M. A., et al.
Published: (2015)

Plasma cathepsin D correlates with histological classifications of fatty liver disease in adults and responds to intervention
by: Walenbergh, Sofie M. A., et al.
Published: (2016)

Is Western Diet-Induced Nonalcoholic Steatohepatitis in Ldlr-/- Mice Reversible?
by: Lytle, Kelli A., et al.
Published: (2016)

Complement Alternative Pathway Activation in Human Nonalcoholic Steatohepatitis
by: Segers, Filip M., et al.
Published: (2014)

Internalization of Modified Lipids by CD36 and SR-A Leads to Hepatic Inflammation and Lysosomal Cholesterol Storage in Kupffer Cells
by: Bieghs, Veerle, et al.
Published: (2012)

A Metabolomic Analysis of Omega-3 Fatty Acid-Mediated Attenuation of Western Diet-Induced Nonalcoholic Steatohepatitis in LDLR -/- Mice
by: Depner, Christopher M., et al.
Published: (2013)

Absence of Elovl6 attenuates steatohepatitis but promotes gallstone formation in a lithogenic diet-fed Ldlr−/− mouse model
by: Kuba, Motoko, et al.
Published: (2015)

LDL Receptor Knock-Out Mice Are a Physiological Model Particularly Vulnerable to Study the Onset of Inflammation in Non-Alcoholic Fatty Liver Disease
by: Bieghs, Veerle, et al.
Published: (2012)

Neutrophil-Derived Myeloperoxidase Aggravates Non-Alcoholic Steatohepatitis in Low-Density Lipoprotein Receptor-Deficient Mice
by: Rensen, Sander S., et al.
Published: (2012)

Intervention with a caspase-1 inhibitor reduces obesity-associated hyperinsulinemia, non-alcoholic steatohepatitis and hepatic fibrosis in LDLR−/−.Leiden mice
by: Morrison, M C, et al.
Published: (2016)

Divergent functions and distinct localization of the Notch ligands DLL1 and DLL3 in vivo
by: Geffers, Insa, et al.
Published: (2007)

Normal Development in Mice Over-Expressing the Intracellular Domain of DLL1 Argues against Reverse Signaling by DLL1 In Vivo
by: Redeker, Christian, et al.
Published: (2013)

Distinct expression patterns of Notch ligands, Dll1 and Dll4, in normal and inflamed mice intestine
by: Shimizu, Hiromichi, et al.
Published: (2014)

Context-Dependent Functional Divergence of the Notch Ligands DLL1 and DLL4 In Vivo
by: Preuße, Kristina, et al.
Published: (2015)

Targeting Notch to overcome radiation resistance
by: Yahyanejad, Sanaz, et al.
Published: (2015)

Oxidized LDL in Inflammation: From Bench to Bedside
by: Tekin, Ishak Ozel, et al.
Published: (2013)

Mediators of Gut Mucosal Immunity and Inflammation
by: Tekin, Ishak Ozel, et al.
Published: (2015)

Clinical implications of DLL4 expression in gastric cancer
by: Ishigami, Sumiya, et al.
Published: (2013)

Macrophage Specific Caspase-1/11 Deficiency Protects against Cholesterol Crystallization and Hepatic Inflammation in Hyperlipidemic Mice
by: Hendrikx, Tim, et al.
Published: (2013)

Primate-specific evolution of an LDLR enhancer
by: Wang, Qian-fei, et al.
Published: (2006)

Protective Role of Plant Sterol and Stanol Esters in Liver Inflammation: Insights from Mice and Humans
by: Plat, Jogchum, et al.
Published: (2014)

Increased Inflammation in Atherosclerotic Lesions of Diabetic Akita-LDLr −/− Mice Compared to Nondiabetic LDLr −/− Mice
by: Engelbertsen, Daniel, et al.
Published: (2012)

HVC1 ameliorates hyperlipidemia and inflammation in LDLR−/− mice
by: Se-Yun Cheon, et al.
Published: (2017-04-01)

Sialic Acid-Binding Immunoglobulin-like Lectin G Promotes Atherosclerosis and Liver Inflammation by Suppressing the Protective Functions of B-1 Cells
by: Gruber, Sabrina, et al.
Published: (2016)

Anti-DLL4, a cancer therapeutic with multiple mechanisms of action
by: Gurney, Austin, et al.
Published: (2011)

Therapeutic promise and challenges of targeting DLL4/NOTCH1
by: Yan, Minhong
Published: (2011)

Dll4-Notch signaling as a therapeutic target in tumor angiogenesis
by: Kuhnert, Frank, et al.
Published: (2011)

O-Fucosylation of DLL3 Is Required for Its Function during Somitogenesis
by: Serth, Katrin, et al.
Published: (2015)

The Regulation of para-Nitrophenol Degradation in Pseudomonas putida DLL-E4
by: Chen, Qiongzhen, et al.
Published: (2016)

Serum Amyloid A Facilitates Early Lesion Development in Ldlr−/− Mice
by: Krishack, Paulette A, et al.
Published: (2015)

DLL4 expression is a prognostic marker and may predict gemcitabine benefit in resected pancreatic cancer
by: Drouillard, A, et al.
Published: (2016)

Recent advances in understanding/management of non-alcoholic steatohepatitis
by: Pacana, Tommy, et al.
Published: (2015)

Dll1 Marks Cells of Origin of Ras-Induced Cancer in Mouse Squamous Epithelia
by: Eleni Vasilaki, et al.
Published: (2018-10-01)

Apoptosis and diagnosis of nonalcoholic steatohepatitis
by: Kim, Chang Wook, et al.
Published: (2011)

Antioxidant Therapy in Nonalcoholic Steatohepatitis
by: Al-Busafi, Said A., et al.
Published: (2012)

The Immune Landscape in Nonalcoholic Steatohepatitis
by: Narayanan, Sowmya, et al.
Published: (2016)

Steatosis and Steatohepatitis: Complex Disorders
by: Bettermann, Kira, et al.
Published: (2014)

Spatiotemporal oscillations of Notch1, Dll1 and NICD are coordinated across the mouse PSM
by: Bone, Robert A., et al.
Published: (2014)