Switching of the positive feedback for RAS activation by a concerted function of SOS membrane association domains
Son of sevenless (SOS) is a guanine nucleotide exchange factor that regulates cell behavior by activating the small GTPase RAS. Recent in vitro studies have suggested that an interaction between SOS and the GTP-bound active form of RAS generates a positive feedback loop that propagates RAS activatio...
| Main Authors: | , , , |
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| Format: | Online |
| Language: | English |
| Published: |
The Biophysical Society of Japan (BSJ)
2016
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042160/ |