Mechanisms through which Sos-1 coordinates the activation of Ras and Rac

Mechanisms through which Sos-1 coordinates the activation of Ras and Rac

Signaling from receptor tyrosine kinases (RTKs)* requires the sequential activation of the small GTPases Ras and Rac. Son of sevenless (Sos-1), a bifunctional guanine nucleotide exchange factor (GEF), activates Ras in vivo and displays Rac-GEF activity in vitro, when engaged in a tricomplex with Eps...

Full description

Bibliographic Details
Main Authors: Innocenti, Metello, Tenca, Pierluigi, Frittoli, Emanuela, Faretta, Mario, Tocchetti, Arianna, Di Fiore, Pier Paolo, Scita, Giorgio
Format: Online
Language:English
Published: The Rockefeller University Press 2002
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173577/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173577/

Similar Items