One-way membrane trafficking of SOS in receptor-triggered Ras activation

One-way membrane trafficking of SOS in receptor-triggered Ras activation

SOS is a key activator of the small GTPase Ras. In cells, SOS-Ras signaling is thought to be initiated predominantly by membrane-recruitment of SOS via the adaptor Grb2 and balanced by rapidly reversible Grb2:SOS binding kinetics. However, SOS has multiple protein and lipid interactions that provide...

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Bibliographic Details
Main Authors: Christensen, Sune M., Tu, Hsiung-Lin, Jun, Jesse E., Alvarez, Steven, Triplet, Meredith G., Iwig, Jeffrey S., Yadav, Kamlesh K., Bar-Sagi, Dafna, Roose, Jeroen P., Groves, Jay T.
Format: Online
Language:English
Published: 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5016256/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5016256/

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