Matrix metalloproteinase inhibitor, doxycycline and progression of calcific aortic valve disease in hyperlipidemic mice

Matrix metalloproteinase inhibitor, doxycycline and progression of calcific aortic valve disease in hyperlipidemic mice

Calcific aortic valve disease (CAVD) is the most common cause of aortic stenosis. Currently, there is no non-invasive medical therapy for CAVD. Matrix metalloproteinases (MMPs) are upregulated in CAVD and play a role in its pathogenesis. Here, we evaluated the effect of doxycycline, a nonselective M...

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Bibliographic Details
Main Authors: Jung, Jae-Joon, Razavian, Mahmoud, Kim, Hye-Yeong, Ye, Yunpeng, Golestani, Reza, Toczek, Jakub, Zhang, Jiasheng, Sadeghi, Mehran M.
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5020643/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5020643/

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