Rescue of mitochondrial function in parkin-mutant fibroblasts using drug loaded PMPC-PDPA polymersomes and tubular polymersomes

Rescue of mitochondrial function in parkin-mutant fibroblasts using drug loaded PMPC-PDPA polymersomes and tubular polymersomes

•Ursolic acid and ursocholanic acid are efficiently encapsulated within PMPC-PDPA polymersomes of spherical or tubular morphology.•PMPC-PDPA polymersomes spherical or tubular morphology are found to enter into parkin-mutant fibroblasts causing no deleterious effects.•ATP levels are increased in park...

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Bibliographic Details
Main Authors: Yealland, G., Battaglia, G., Bandmann, O., Mortiboys, H
Format: Online
Language:English
Published: Elsevier Scientific Publishers Ireland 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010038/

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