Rescue of mitochondrial function in parkin-mutant fibroblasts using drug loaded PMPC-PDPA polymersomes and tubular polymersomes
•Ursolic acid and ursocholanic acid are efficiently encapsulated within PMPC-PDPA polymersomes of spherical or tubular morphology.•PMPC-PDPA polymersomes spherical or tubular morphology are found to enter into parkin-mutant fibroblasts causing no deleterious effects.•ATP levels are increased in park...
| Main Authors: | , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Elsevier Scientific Publishers Ireland
2016
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010038/ |
| Summary: | •Ursolic acid and ursocholanic acid are efficiently encapsulated within PMPC-PDPA polymersomes of spherical or tubular morphology.•PMPC-PDPA polymersomes spherical or tubular morphology are found to enter into parkin-mutant fibroblasts causing no deleterious effects.•ATP levels are increased in parkin-mutant fibroblasts after incubation with ursolic or ursocholanic acid loaded PMPC-PDPA polymersomes.•The efficacy of ursolic acid and ursochocholanic acid loaded PMPC-PDPA nanoparticles is similar to DMSO based formulations of the same compounds. |
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