Phosphorylation of Mitochondrial Polyubiquitin by PINK1 Promotes Parkin Mitochondrial Tethering

Phosphorylation of Mitochondrial Polyubiquitin by PINK1 Promotes Parkin Mitochondrial Tethering

The kinase PINK1 and the E3 ubiquitin (Ub) ligase Parkin participate in mitochondrial quality control. The phosphorylation of Ser65 in Parkin's ubiquitin-like (UBl) domain by PINK1 stimulates Parkin activation and translocation to damaged mitochondria, which induces mitophagy generating polyUb...

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Bibliographic Details
Main Authors: Shiba-Fukushima, Kahori, Arano, Taku, Matsumoto, Gen, Inoshita, Tsuyoshi, Yoshida, Shigeharu, Ishihama, Yasushi, Ryu, Kwon-Yul, Nukina, Nobuyuki, Hattori, Nobutaka, Imai, Yuzuru
Format: Online
Language:English
Published: Public Library of Science 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256268/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256268/

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