Mechanism of phospho-ubiquitin induced PARKIN activation

The E3 ubiquitin ligase PARKIN (encoded by PARK2) and the protein kinase PINK1 (encoded by PARK6) are mutated in autosomal recessive juvenile Parkinsonism (AR-JP) and work together in the disposal of damaged mitochondria by mitophagy1–3. PINK1 is stabilised on the outside of depolarised mitochondria...

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Main Authors:	Wauer, Tobias, Simicek, Michal, Schubert, Alexander, Komander, David
Format:	Online
Language:	English
Published:	2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4984986/

id	pubmed-4984986
recordtype	oai_dc
spelling	pubmed-49849862016-08-15 Mechanism of phospho-ubiquitin induced PARKIN activation Wauer, Tobias Simicek, Michal Schubert, Alexander Komander, David Article The E3 ubiquitin ligase PARKIN (encoded by PARK2) and the protein kinase PINK1 (encoded by PARK6) are mutated in autosomal recessive juvenile Parkinsonism (AR-JP) and work together in the disposal of damaged mitochondria by mitophagy1–3. PINK1 is stabilised on the outside of depolarised mitochondria, and phosphorylates poly-ubiquitin (polyUb)4–8 as well as the PARKIN Ub-like (Ubl) domain9,10. These phosphorylation events lead to PARKIN recruitment to mitochondria, and activation by an unknown allosteric mechanism4–12. 2015-07-10 2015-08-20 /pmc/articles/PMC4984986/ /pubmed/26161729 http://dx.doi.org/10.1038/nature14879 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Wauer, Tobias Simicek, Michal Schubert, Alexander Komander, David
spellingShingle	Wauer, Tobias Simicek, Michal Schubert, Alexander Komander, David Mechanism of phospho-ubiquitin induced PARKIN activation
author_facet	Wauer, Tobias Simicek, Michal Schubert, Alexander Komander, David
author_sort	Wauer, Tobias
title	Mechanism of phospho-ubiquitin induced PARKIN activation
title_short	Mechanism of phospho-ubiquitin induced PARKIN activation
title_full	Mechanism of phospho-ubiquitin induced PARKIN activation
title_fullStr	Mechanism of phospho-ubiquitin induced PARKIN activation
title_full_unstemmed	Mechanism of phospho-ubiquitin induced PARKIN activation
title_sort	mechanism of phospho-ubiquitin induced parkin activation
description	The E3 ubiquitin ligase PARKIN (encoded by PARK2) and the protein kinase PINK1 (encoded by PARK6) are mutated in autosomal recessive juvenile Parkinsonism (AR-JP) and work together in the disposal of damaged mitochondria by mitophagy1–3. PINK1 is stabilised on the outside of depolarised mitochondria, and phosphorylates poly-ubiquitin (polyUb)4–8 as well as the PARKIN Ub-like (Ubl) domain9,10. These phosphorylation events lead to PARKIN recruitment to mitochondria, and activation by an unknown allosteric mechanism4–12.
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4984986/
_version_	1613627471838576640

Mechanism of phospho-ubiquitin induced PARKIN activation

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