Fine-Scale Mapping at 9p22.2 Identifies Candidate Causal Variants That Modify Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers
Population-based genome wide association studies have identified a locus at 9p22.2 associated with ovarian cancer risk, which also modifies ovarian cancer risk in BRCA1 and BRCA2 mutation carriers. We conducted fine-scale mapping at 9p22.2 to identify potential causal variants in BRCA1 and BRCA2 mut...
Similar Items
-
Comparative In Vitro and In Silico Analyses of Variants in Splicing Regions of BRCA1 and BRCA2 Genes and Characterization of Novel Pathogenic Mutations
by: Colombo, Mara, et al.
Published: (2013) -
Inheritance of deleterious mutations at both BRCA1 and BRCA2 in an international sample of 32,295 women
by: Rebbeck, Timothy R., et al.
Published: (2016) -
Haplotype analysis in German families with recurrent BRCA1 and BRCA2 mutations
by: Wappenschmidt, B, et al.
Published: (2001) -
Hereditary Susceptibility to Breast Cancer: Significance of Age of Onset in Family History and Contribution of BRCA1 and BRCA2
by: Frank, Thomas S., et al.
Published: (1999) -
The incidence of pancreatic cancer in BRCA1 and BRCA2 mutation carriers
by: Iqbal, J, et al.
Published: (2012)