Fine-Scale Mapping at 9p22.2 Identifies Candidate Causal Variants That Modify Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers

Population-based genome wide association studies have identified a locus at 9p22.2 associated with ovarian cancer risk, which also modifies ovarian cancer risk in BRCA1 and BRCA2 mutation carriers. We conducted fine-scale mapping at 9p22.2 to identify potential causal variants in BRCA1 and BRCA2 mut...

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Main Authors:	Vigorito, Elena, Kuchenbaecker, Karoline B., Beesley, Jonathan, Adlard, Julian, Agnarsson, Bjarni A., Andrulis, Irene L., Arun, Banu K., Barjhoux, Laure, Belotti, Muriel, Benitez, Javier, Berger, Andreas, Bojesen, Anders, Bonanni, Bernardo, Brewer, Carole, Caldes, Trinidad, Caligo, Maria A., Campbell, Ian, Chan, Salina B., Claes, Kathleen B. M., Cohn, David E., Cook, Jackie, Daly, Mary B., Damiola, Francesca, Davidson, Rosemarie, de Pauw, Antoine, Delnatte, Capucine, Diez, Orland, Domchek, Susan M., Dumont, Martine, Durda, Katarzyna, Dworniczak, Bernd, Easton, Douglas F., Eccles, Diana, Edwinsdotter Ardnor, Christina, Eeles, Ros, Ejlertsen, Bent, Ellis, Steve, Evans, D. Gareth, Feliubadalo, Lidia, Fostira, Florentia, Foulkes, William D., Friedman, Eitan, Frost, Debra, Gaddam, Pragna, Ganz, Patricia A., Garber, Judy, Garcia-Barberan, Vanesa, Gauthier-Villars, Marion, Gehrig, Andrea, Gerdes, Anne-Marie, Giraud, Sophie, Godwin, Andrew K., Goldgar, David E., Hake, Christopher R., Hansen, Thomas V. O., Healey, Sue, Hodgson, Shirley, Hogervorst, Frans B. L., Houdayer, Claude, Hulick, Peter J., Imyanitov, Evgeny N., Isaacs, Claudine, Izatt, Louise, Izquierdo, Angel, Jacobs, Lauren, Jakubowska, Anna, Janavicius, Ramunas, Jaworska-Bieniek, Katarzyna, Jensen, Uffe Birk, John, Esther M., Vijai, Joseph, Karlan, Beth Y., Kast, Karin, Investigators, KConFab, Khan, Sofia, Kwong, Ava, Laitman, Yael, Lester, Jenny, Lesueur, Fabienne, Liljegren, Annelie, Lubinski, Jan, Mai, Phuong L., Manoukian, Siranoush, Mazoyer, Sylvie, Meindl, Alfons, Mensenkamp, Arjen R., Montagna, Marco, Nathanson, Katherine L., Neuhausen, Susan L., Nevanlinna, Heli, Niederacher, Dieter, Olah, Edith, Olopade, Olufunmilayo I., Ong, Kai-ren, Osorio, Ana, Park, Sue Kyung, Paulsson-Karlsson, Ylva, Pedersen, Inge Sokilde, Peissel, Bernard, Peterlongo, Paolo, Pfeiler, Georg, Phelan, Catherine M., Piedmonte, Marion, Poppe, Bruce, Pujana, Miquel Angel, Radice, Paolo, Rennert, Gad, Rodriguez, Gustavo C., Rookus, Matti A., Ross, Eric A., Schmutzler, Rita Katharina, Simard, Jacques, Singer, Christian F., Slavin, Thomas P., Soucy, Penny, Southey, Melissa, Steinemann, Doris, Stoppa-Lyonnet, Dominique, Sukiennicki, Grzegorz, Sutter, Christian, Szabo, Csilla I., Tea, Muy-Kheng, Teixeira, Manuel R., Teo, Soo-Hwang, Terry, Mary Beth, Thomassen, Mads, Tibiletti, Maria Grazia, Tihomirova, Laima, Tognazzo, Silvia, van Rensburg, Elizabeth J., Varesco, Liliana, Varon-Mateeva, Raymonda, Vratimos, Athanassios, Weitzel, Jeffrey N., McGuffog, Lesley, Kirk, Judy, Toland, Amanda Ewart, Hamann, Ute, Lindor, Noralane, Ramus, Susan J., Greene, Mark H., Couch, Fergus J., Offit, Kenneth, Pharoah, Paul D. P., Chenevix-Trench, Georgia, Antoniou, Antonis C.
Format:	Online
Language:	English
Published:	Public Library of Science 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963094/

id	pubmed-4963094
recordtype	oai_dc
spelling	pubmed-49630942016-08-08 Fine-Scale Mapping at 9p22.2 Identifies Candidate Causal Variants That Modify Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers Vigorito, Elena Kuchenbaecker, Karoline B. Beesley, Jonathan Adlard, Julian Agnarsson, Bjarni A. Andrulis, Irene L. Arun, Banu K. Barjhoux, Laure Belotti, Muriel Benitez, Javier Berger, Andreas Bojesen, Anders Bonanni, Bernardo Brewer, Carole Caldes, Trinidad Caligo, Maria A. Campbell, Ian Chan, Salina B. Claes, Kathleen B. M. Cohn, David E. Cook, Jackie Daly, Mary B. Damiola, Francesca Davidson, Rosemarie de Pauw, Antoine Delnatte, Capucine Diez, Orland Domchek, Susan M. Dumont, Martine Durda, Katarzyna Dworniczak, Bernd Easton, Douglas F. Eccles, Diana Edwinsdotter Ardnor, Christina Eeles, Ros Ejlertsen, Bent Ellis, Steve Evans, D. Gareth Feliubadalo, Lidia Fostira, Florentia Foulkes, William D. Friedman, Eitan Frost, Debra Gaddam, Pragna Ganz, Patricia A. Garber, Judy Garcia-Barberan, Vanesa Gauthier-Villars, Marion Gehrig, Andrea Gerdes, Anne-Marie Giraud, Sophie Godwin, Andrew K. Goldgar, David E. Hake, Christopher R. Hansen, Thomas V. O. Healey, Sue Hodgson, Shirley Hogervorst, Frans B. L. Houdayer, Claude Hulick, Peter J. Imyanitov, Evgeny N. Isaacs, Claudine Izatt, Louise Izquierdo, Angel Jacobs, Lauren Jakubowska, Anna Janavicius, Ramunas Jaworska-Bieniek, Katarzyna Jensen, Uffe Birk John, Esther M. Vijai, Joseph Karlan, Beth Y. Kast, Karin Investigators, KConFab Khan, Sofia Kwong, Ava Laitman, Yael Lester, Jenny Lesueur, Fabienne Liljegren, Annelie Lubinski, Jan Mai, Phuong L. Manoukian, Siranoush Mazoyer, Sylvie Meindl, Alfons Mensenkamp, Arjen R. Montagna, Marco Nathanson, Katherine L. Neuhausen, Susan L. Nevanlinna, Heli Niederacher, Dieter Olah, Edith Olopade, Olufunmilayo I. Ong, Kai-ren Osorio, Ana Park, Sue Kyung Paulsson-Karlsson, Ylva Pedersen, Inge Sokilde Peissel, Bernard Peterlongo, Paolo Pfeiler, Georg Phelan, Catherine M. Piedmonte, Marion Poppe, Bruce Pujana, Miquel Angel Radice, Paolo Rennert, Gad Rodriguez, Gustavo C. Rookus, Matti A. Ross, Eric A. Schmutzler, Rita Katharina Simard, Jacques Singer, Christian F. Slavin, Thomas P. Soucy, Penny Southey, Melissa Steinemann, Doris Stoppa-Lyonnet, Dominique Sukiennicki, Grzegorz Sutter, Christian Szabo, Csilla I. Tea, Muy-Kheng Teixeira, Manuel R. Teo, Soo-Hwang Terry, Mary Beth Thomassen, Mads Tibiletti, Maria Grazia Tihomirova, Laima Tognazzo, Silvia van Rensburg, Elizabeth J. Varesco, Liliana Varon-Mateeva, Raymonda Vratimos, Athanassios Weitzel, Jeffrey N. McGuffog, Lesley Kirk, Judy Toland, Amanda Ewart Hamann, Ute Lindor, Noralane Ramus, Susan J. Greene, Mark H. Couch, Fergus J. Offit, Kenneth Pharoah, Paul D. P. Chenevix-Trench, Georgia Antoniou, Antonis C. Research Article Population-based genome wide association studies have identified a locus at 9p22.2 associated with ovarian cancer risk, which also modifies ovarian cancer risk in BRCA1 and BRCA2 mutation carriers. We conducted fine-scale mapping at 9p22.2 to identify potential causal variants in BRCA1 and BRCA2 mutation carriers. Genotype data were available for 15,252 (2,462 ovarian cancer cases) BRCA1 and 8,211 (631 ovarian cancer cases) BRCA2 mutation carriers. Following genotype imputation, ovarian cancer associations were assessed for 4,873 and 5,020 SNPs in BRCA1 and BRCA 2 mutation carriers respectively, within a retrospective cohort analytical framework. In BRCA1 mutation carriers one set of eight correlated candidate causal variants for ovarian cancer risk modification was identified (top SNP rs10124837, HR: 0.73, 95%CI: 0.68 to 0.79, p-value 2× 10−16). These variants were located up to 20 kb upstream of BNC2. In BRCA2 mutation carriers one region, up to 45 kb upstream of BNC2, and containing 100 correlated SNPs was identified as candidate causal (top SNP rs62543585, HR: 0.69, 95%CI: 0.59 to 0.80, p-value 1.0 × 10−6). The candidate causal in BRCA1 mutation carriers did not include the strongest associated variant at this locus in the general population. In sum, we identified a set of candidate causal variants in a region that encompasses the BNC2 transcription start site. The ovarian cancer association at 9p22.2 may be mediated by different variants in BRCA1 mutation carriers and in the general population. Thus, potentially different mechanisms may underlie ovarian cancer risk for mutation carriers and the general population. Public Library of Science 2016-07-27 /pmc/articles/PMC4963094/ /pubmed/27463617 http://dx.doi.org/10.1371/journal.pone.0158801 Text en https://creativecommons.org/publicdomain/zero/1.0/ This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 (https://creativecommons.org/publicdomain/zero/1.0/) public domain dedication.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Vigorito, Elena Kuchenbaecker, Karoline B. Beesley, Jonathan Adlard, Julian Agnarsson, Bjarni A. Andrulis, Irene L. Arun, Banu K. Barjhoux, Laure Belotti, Muriel Benitez, Javier Berger, Andreas Bojesen, Anders Bonanni, Bernardo Brewer, Carole Caldes, Trinidad Caligo, Maria A. Campbell, Ian Chan, Salina B. Claes, Kathleen B. M. Cohn, David E. Cook, Jackie Daly, Mary B. Damiola, Francesca Davidson, Rosemarie de Pauw, Antoine Delnatte, Capucine Diez, Orland Domchek, Susan M. Dumont, Martine Durda, Katarzyna Dworniczak, Bernd Easton, Douglas F. Eccles, Diana Edwinsdotter Ardnor, Christina Eeles, Ros Ejlertsen, Bent Ellis, Steve Evans, D. Gareth Feliubadalo, Lidia Fostira, Florentia Foulkes, William D. Friedman, Eitan Frost, Debra Gaddam, Pragna Ganz, Patricia A. Garber, Judy Garcia-Barberan, Vanesa Gauthier-Villars, Marion Gehrig, Andrea Gerdes, Anne-Marie Giraud, Sophie Godwin, Andrew K. Goldgar, David E. Hake, Christopher R. Hansen, Thomas V. O. Healey, Sue Hodgson, Shirley Hogervorst, Frans B. L. Houdayer, Claude Hulick, Peter J. Imyanitov, Evgeny N. Isaacs, Claudine Izatt, Louise Izquierdo, Angel Jacobs, Lauren Jakubowska, Anna Janavicius, Ramunas Jaworska-Bieniek, Katarzyna Jensen, Uffe Birk John, Esther M. Vijai, Joseph Karlan, Beth Y. Kast, Karin Investigators, KConFab Khan, Sofia Kwong, Ava Laitman, Yael Lester, Jenny Lesueur, Fabienne Liljegren, Annelie Lubinski, Jan Mai, Phuong L. Manoukian, Siranoush Mazoyer, Sylvie Meindl, Alfons Mensenkamp, Arjen R. Montagna, Marco Nathanson, Katherine L. Neuhausen, Susan L. Nevanlinna, Heli Niederacher, Dieter Olah, Edith Olopade, Olufunmilayo I. Ong, Kai-ren Osorio, Ana Park, Sue Kyung Paulsson-Karlsson, Ylva Pedersen, Inge Sokilde Peissel, Bernard Peterlongo, Paolo Pfeiler, Georg Phelan, Catherine M. Piedmonte, Marion Poppe, Bruce Pujana, Miquel Angel Radice, Paolo Rennert, Gad Rodriguez, Gustavo C. Rookus, Matti A. Ross, Eric A. Schmutzler, Rita Katharina Simard, Jacques Singer, Christian F. Slavin, Thomas P. Soucy, Penny Southey, Melissa Steinemann, Doris Stoppa-Lyonnet, Dominique Sukiennicki, Grzegorz Sutter, Christian Szabo, Csilla I. Tea, Muy-Kheng Teixeira, Manuel R. Teo, Soo-Hwang Terry, Mary Beth Thomassen, Mads Tibiletti, Maria Grazia Tihomirova, Laima Tognazzo, Silvia van Rensburg, Elizabeth J. Varesco, Liliana Varon-Mateeva, Raymonda Vratimos, Athanassios Weitzel, Jeffrey N. McGuffog, Lesley Kirk, Judy Toland, Amanda Ewart Hamann, Ute Lindor, Noralane Ramus, Susan J. Greene, Mark H. Couch, Fergus J. Offit, Kenneth Pharoah, Paul D. P. Chenevix-Trench, Georgia Antoniou, Antonis C.
spellingShingle	Vigorito, Elena Kuchenbaecker, Karoline B. Beesley, Jonathan Adlard, Julian Agnarsson, Bjarni A. Andrulis, Irene L. Arun, Banu K. Barjhoux, Laure Belotti, Muriel Benitez, Javier Berger, Andreas Bojesen, Anders Bonanni, Bernardo Brewer, Carole Caldes, Trinidad Caligo, Maria A. Campbell, Ian Chan, Salina B. Claes, Kathleen B. M. Cohn, David E. Cook, Jackie Daly, Mary B. Damiola, Francesca Davidson, Rosemarie de Pauw, Antoine Delnatte, Capucine Diez, Orland Domchek, Susan M. Dumont, Martine Durda, Katarzyna Dworniczak, Bernd Easton, Douglas F. Eccles, Diana Edwinsdotter Ardnor, Christina Eeles, Ros Ejlertsen, Bent Ellis, Steve Evans, D. Gareth Feliubadalo, Lidia Fostira, Florentia Foulkes, William D. Friedman, Eitan Frost, Debra Gaddam, Pragna Ganz, Patricia A. Garber, Judy Garcia-Barberan, Vanesa Gauthier-Villars, Marion Gehrig, Andrea Gerdes, Anne-Marie Giraud, Sophie Godwin, Andrew K. Goldgar, David E. Hake, Christopher R. Hansen, Thomas V. O. Healey, Sue Hodgson, Shirley Hogervorst, Frans B. L. Houdayer, Claude Hulick, Peter J. Imyanitov, Evgeny N. Isaacs, Claudine Izatt, Louise Izquierdo, Angel Jacobs, Lauren Jakubowska, Anna Janavicius, Ramunas Jaworska-Bieniek, Katarzyna Jensen, Uffe Birk John, Esther M. Vijai, Joseph Karlan, Beth Y. Kast, Karin Investigators, KConFab Khan, Sofia Kwong, Ava Laitman, Yael Lester, Jenny Lesueur, Fabienne Liljegren, Annelie Lubinski, Jan Mai, Phuong L. Manoukian, Siranoush Mazoyer, Sylvie Meindl, Alfons Mensenkamp, Arjen R. Montagna, Marco Nathanson, Katherine L. Neuhausen, Susan L. Nevanlinna, Heli Niederacher, Dieter Olah, Edith Olopade, Olufunmilayo I. Ong, Kai-ren Osorio, Ana Park, Sue Kyung Paulsson-Karlsson, Ylva Pedersen, Inge Sokilde Peissel, Bernard Peterlongo, Paolo Pfeiler, Georg Phelan, Catherine M. Piedmonte, Marion Poppe, Bruce Pujana, Miquel Angel Radice, Paolo Rennert, Gad Rodriguez, Gustavo C. Rookus, Matti A. Ross, Eric A. Schmutzler, Rita Katharina Simard, Jacques Singer, Christian F. Slavin, Thomas P. Soucy, Penny Southey, Melissa Steinemann, Doris Stoppa-Lyonnet, Dominique Sukiennicki, Grzegorz Sutter, Christian Szabo, Csilla I. Tea, Muy-Kheng Teixeira, Manuel R. Teo, Soo-Hwang Terry, Mary Beth Thomassen, Mads Tibiletti, Maria Grazia Tihomirova, Laima Tognazzo, Silvia van Rensburg, Elizabeth J. Varesco, Liliana Varon-Mateeva, Raymonda Vratimos, Athanassios Weitzel, Jeffrey N. McGuffog, Lesley Kirk, Judy Toland, Amanda Ewart Hamann, Ute Lindor, Noralane Ramus, Susan J. Greene, Mark H. Couch, Fergus J. Offit, Kenneth Pharoah, Paul D. P. Chenevix-Trench, Georgia Antoniou, Antonis C. Fine-Scale Mapping at 9p22.2 Identifies Candidate Causal Variants That Modify Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers
author_facet	Vigorito, Elena Kuchenbaecker, Karoline B. Beesley, Jonathan Adlard, Julian Agnarsson, Bjarni A. Andrulis, Irene L. Arun, Banu K. Barjhoux, Laure Belotti, Muriel Benitez, Javier Berger, Andreas Bojesen, Anders Bonanni, Bernardo Brewer, Carole Caldes, Trinidad Caligo, Maria A. Campbell, Ian Chan, Salina B. Claes, Kathleen B. M. Cohn, David E. Cook, Jackie Daly, Mary B. Damiola, Francesca Davidson, Rosemarie de Pauw, Antoine Delnatte, Capucine Diez, Orland Domchek, Susan M. Dumont, Martine Durda, Katarzyna Dworniczak, Bernd Easton, Douglas F. Eccles, Diana Edwinsdotter Ardnor, Christina Eeles, Ros Ejlertsen, Bent Ellis, Steve Evans, D. Gareth Feliubadalo, Lidia Fostira, Florentia Foulkes, William D. Friedman, Eitan Frost, Debra Gaddam, Pragna Ganz, Patricia A. Garber, Judy Garcia-Barberan, Vanesa Gauthier-Villars, Marion Gehrig, Andrea Gerdes, Anne-Marie Giraud, Sophie Godwin, Andrew K. Goldgar, David E. Hake, Christopher R. Hansen, Thomas V. O. Healey, Sue Hodgson, Shirley Hogervorst, Frans B. L. Houdayer, Claude Hulick, Peter J. Imyanitov, Evgeny N. Isaacs, Claudine Izatt, Louise Izquierdo, Angel Jacobs, Lauren Jakubowska, Anna Janavicius, Ramunas Jaworska-Bieniek, Katarzyna Jensen, Uffe Birk John, Esther M. Vijai, Joseph Karlan, Beth Y. Kast, Karin Investigators, KConFab Khan, Sofia Kwong, Ava Laitman, Yael Lester, Jenny Lesueur, Fabienne Liljegren, Annelie Lubinski, Jan Mai, Phuong L. Manoukian, Siranoush Mazoyer, Sylvie Meindl, Alfons Mensenkamp, Arjen R. Montagna, Marco Nathanson, Katherine L. Neuhausen, Susan L. Nevanlinna, Heli Niederacher, Dieter Olah, Edith Olopade, Olufunmilayo I. Ong, Kai-ren Osorio, Ana Park, Sue Kyung Paulsson-Karlsson, Ylva Pedersen, Inge Sokilde Peissel, Bernard Peterlongo, Paolo Pfeiler, Georg Phelan, Catherine M. Piedmonte, Marion Poppe, Bruce Pujana, Miquel Angel Radice, Paolo Rennert, Gad Rodriguez, Gustavo C. Rookus, Matti A. Ross, Eric A. Schmutzler, Rita Katharina Simard, Jacques Singer, Christian F. Slavin, Thomas P. Soucy, Penny Southey, Melissa Steinemann, Doris Stoppa-Lyonnet, Dominique Sukiennicki, Grzegorz Sutter, Christian Szabo, Csilla I. Tea, Muy-Kheng Teixeira, Manuel R. Teo, Soo-Hwang Terry, Mary Beth Thomassen, Mads Tibiletti, Maria Grazia Tihomirova, Laima Tognazzo, Silvia van Rensburg, Elizabeth J. Varesco, Liliana Varon-Mateeva, Raymonda Vratimos, Athanassios Weitzel, Jeffrey N. McGuffog, Lesley Kirk, Judy Toland, Amanda Ewart Hamann, Ute Lindor, Noralane Ramus, Susan J. Greene, Mark H. Couch, Fergus J. Offit, Kenneth Pharoah, Paul D. P. Chenevix-Trench, Georgia Antoniou, Antonis C.
author_sort	Vigorito, Elena
title	Fine-Scale Mapping at 9p22.2 Identifies Candidate Causal Variants That Modify Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers
title_short	Fine-Scale Mapping at 9p22.2 Identifies Candidate Causal Variants That Modify Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers
title_full	Fine-Scale Mapping at 9p22.2 Identifies Candidate Causal Variants That Modify Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers
title_fullStr	Fine-Scale Mapping at 9p22.2 Identifies Candidate Causal Variants That Modify Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers
title_full_unstemmed	Fine-Scale Mapping at 9p22.2 Identifies Candidate Causal Variants That Modify Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers
title_sort	fine-scale mapping at 9p22.2 identifies candidate causal variants that modify ovarian cancer risk in brca1 and brca2 mutation carriers
description	Population-based genome wide association studies have identified a locus at 9p22.2 associated with ovarian cancer risk, which also modifies ovarian cancer risk in BRCA1 and BRCA2 mutation carriers. We conducted fine-scale mapping at 9p22.2 to identify potential causal variants in BRCA1 and BRCA2 mutation carriers. Genotype data were available for 15,252 (2,462 ovarian cancer cases) BRCA1 and 8,211 (631 ovarian cancer cases) BRCA2 mutation carriers. Following genotype imputation, ovarian cancer associations were assessed for 4,873 and 5,020 SNPs in BRCA1 and BRCA 2 mutation carriers respectively, within a retrospective cohort analytical framework. In BRCA1 mutation carriers one set of eight correlated candidate causal variants for ovarian cancer risk modification was identified (top SNP rs10124837, HR: 0.73, 95%CI: 0.68 to 0.79, p-value 2× 10−16). These variants were located up to 20 kb upstream of BNC2. In BRCA2 mutation carriers one region, up to 45 kb upstream of BNC2, and containing 100 correlated SNPs was identified as candidate causal (top SNP rs62543585, HR: 0.69, 95%CI: 0.59 to 0.80, p-value 1.0 × 10−6). The candidate causal in BRCA1 mutation carriers did not include the strongest associated variant at this locus in the general population. In sum, we identified a set of candidate causal variants in a region that encompasses the BNC2 transcription start site. The ovarian cancer association at 9p22.2 may be mediated by different variants in BRCA1 mutation carriers and in the general population. Thus, potentially different mechanisms may underlie ovarian cancer risk for mutation carriers and the general population.
publisher	Public Library of Science
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963094/
_version_	1613616119941169152

Fine-Scale Mapping at 9p22.2 Identifies Candidate Causal Variants That Modify Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers

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