Role of NLRP3 Inflammasome in the Progression of NAFLD to NASH
Nonalcoholic fatty liver disease (NAFLD) has been recognized as a major public health problem worldwide. Nonalcoholic steatohepatitis (NASH) is an advanced form of NAFLD that may progress to cirrhosis and hepatocellular carcinoma. The pathogenesis of disease progression from NAFLD to NASH has not be...
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| Format: | Online |
| Language: | English |
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Hindawi Publishing Corporation
2016
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904645/ |
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pubmed-4904645 |
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pubmed-49046452016-06-30 Role of NLRP3 Inflammasome in the Progression of NAFLD to NASH Wan, Xingyong Xu, Chengfu Yu, Chaohui Li, Youming Review Article Nonalcoholic fatty liver disease (NAFLD) has been recognized as a major public health problem worldwide. Nonalcoholic steatohepatitis (NASH) is an advanced form of NAFLD that may progress to cirrhosis and hepatocellular carcinoma. The pathogenesis of disease progression from NAFLD to NASH has not been fully understood. Immunological mechanisms that have been increasingly recognized in the disease progression include defects in innate immunity, adaptive immunity, Toll-like receptor (TLR) signaling, and gut-liver axis. The NLRP3 inflammasome is an intracellular multiprotein complex involved in the production of mature interleukin 1-beta (IL-1β) and induces metabolic inflammation. NLRP3 inflammasome has been recently demonstrated to play a crucial role in the progression of NASH. This review highlights the recent findings linking NLRP3 inflammasome to the progression of NASH. Hindawi Publishing Corporation 2016 2016-05-04 /pmc/articles/PMC4904645/ /pubmed/27446858 http://dx.doi.org/10.1155/2016/6489012 Text en Copyright © 2016 Xingyong Wan et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Wan, Xingyong Xu, Chengfu Yu, Chaohui Li, Youming |
| spellingShingle |
Wan, Xingyong Xu, Chengfu Yu, Chaohui Li, Youming Role of NLRP3 Inflammasome in the Progression of NAFLD to NASH |
| author_facet |
Wan, Xingyong Xu, Chengfu Yu, Chaohui Li, Youming |
| author_sort |
Wan, Xingyong |
| title |
Role of NLRP3 Inflammasome in the Progression of NAFLD to NASH |
| title_short |
Role of NLRP3 Inflammasome in the Progression of NAFLD to NASH |
| title_full |
Role of NLRP3 Inflammasome in the Progression of NAFLD to NASH |
| title_fullStr |
Role of NLRP3 Inflammasome in the Progression of NAFLD to NASH |
| title_full_unstemmed |
Role of NLRP3 Inflammasome in the Progression of NAFLD to NASH |
| title_sort |
role of nlrp3 inflammasome in the progression of nafld to nash |
| description |
Nonalcoholic fatty liver disease (NAFLD) has been recognized as a major public health problem worldwide. Nonalcoholic steatohepatitis (NASH) is an advanced form of NAFLD that may progress to cirrhosis and hepatocellular carcinoma. The pathogenesis of disease progression from NAFLD to NASH has not been fully understood. Immunological mechanisms that have been increasingly recognized in the disease progression include defects in innate immunity, adaptive immunity, Toll-like receptor (TLR) signaling, and gut-liver axis. The NLRP3 inflammasome is an intracellular multiprotein complex involved in the production of mature interleukin 1-beta (IL-1β) and induces metabolic inflammation. NLRP3 inflammasome has been recently demonstrated to play a crucial role in the progression of NASH. This review highlights the recent findings linking NLRP3 inflammasome to the progression of NASH. |
| publisher |
Hindawi Publishing Corporation |
| publishDate |
2016 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904645/ |
| _version_ |
1613593523160875008 |