Overexpression of a glucokinase point mutant in the treatment of diabetes mellitus

Overexpression of a glucokinase point mutant in the treatment of diabetes mellitus

Glucokinase (GCK) is an important enzyme critical for glucose metabolism, and has been targeted as such in the pursuit of a cure for diabetes mellitus. We show that streptozotocin (STZ)-induced diabetic murine model exhibits low GCK expression with high blood glucose levels; moreover, aggravated glo...

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Bibliographic Details
Main Authors: Lu, G, Teng, X, Zheng, Z, Zhang, R, Peng, L, Zheng, F, Liu, J, Huang, H, Xiong, H
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4827006/

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