Insulin-Receptor Substrate-2 (IRS-2) Is Required for Maintaining Glucokinase and Glucokinase Regulatory Protein Expression in Mouse Liver

Insulin-Receptor Substrate-2 (IRS-2) Is Required for Maintaining Glucokinase and Glucokinase Regulatory Protein Expression in Mouse Liver

Insulin receptor substrate (IRS) proteins play important roles in hepatic nutrient homeostasis. Since glucokinase (GK) and glucokinase regulatory protein (GKRP) function as key glucose sensors, we have investigated the expression of GK and GKRP in liver of Irs-2 deficient mice and Irs2(−/−) mice whe...

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Bibliographic Details
Main Authors: Roncero, Isabel, Alvarez, Elvira, Acosta, Carlos, Sanz, Carmen, Barrio, Pedro, Hurtado-Carneiro, Veronica, Burks, Deborah, Blázquez, Enrique
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613347/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613347/

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