The Hepatoselective Glucokinase Activator PF-04991532 Ameliorates Hyperglycemia without Causing Hepatic Steatosis in Diabetic Rats

The Hepatoselective Glucokinase Activator PF-04991532 Ameliorates Hyperglycemia without Causing Hepatic Steatosis in Diabetic Rats

Hyperglycemia resulting from type 2 diabetes mellitus (T2DM) is the main cause of diabetic complications such as retinopathy and neuropathy. A reduction in hyperglycemia has been shown to prevent these associated complications supporting the importance of glucose control. Glucokinase converts glucos...

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Bibliographic Details
Main Authors: Erion, Derek M., Lapworth, Amanda, Amor, Paul A., Bai, Guoyun, Vera, Nicholas B., Clark, Ronald W., Yan, Qingyun, Zhu, Yimin, Ross, Trenton T., Purkal, Julie, Gorgoglione, Matthew, Zhang, Guodong, Bonato, Vinicius, Baker, Levenia, Barucci, Nicole, D’Aquila, Theresa, Robertson, Alan, Aiello, Robert J., Yan, Jiangli, Trimmer, Jeff, Rolph, Timothy P., Pfefferkorn, Jeffrey A.
Format: Online
Language:English
Published: Public Library of Science 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032240/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032240/

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