Therapeutic targeting and rapid mobilization of endosteal HSC using a small molecule integrin antagonist
The inherent disadvantages of using granulocyte colony-stimulating factor (G-CSF) for hematopoietic stem cell (HSC) mobilization have driven efforts to identify alternate strategies based on single doses of small molecules. Here, we show targeting α9β1/α4β1 integrins with a single dose of a small mo...
Main Authors: | Cao, Benjamin, Zhang, Zhen, Grassinger, Jochen, Williams, Brenda, Heazlewood, Chad K., Churches, Quentin I., James, Simon A., Li, Songhui, Papayannopoulou, Thalia, Nilsson, Susan K. |
---|---|
Format: | Online |
Language: | English |
Published: |
Nature Publishing Group
2016
|
Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4796355/ |
Similar Items
-
Vascularised endosteal bone tissue in armoured sauropod dinosaurs
by: Chinsamy, Anusuya, et al.
Published: (2016) -
HIF-1 and its antagonist Cited2: Regulators of HSC quiescence
by: Du, Jinwei, et al.
Published: (2012) -
Osteoclasts control reactivation of dormant myeloma cells by remodelling the endosteal niche
by: Lawson, Michelle A., et al.
Published: (2015) -
Generation and Characterization of Erythroid Cells from Human Embryonic Stem Cells and Induced Pluripotent Stem Cells: An Overview
by: Chang, Kai-Hsin, et al.
Published: (2011) -
Hsc70’s trip to the tip
by: Leslie, Mitch
Published: (2015)