Therapeutic targeting and rapid mobilization of endosteal HSC using a small molecule integrin antagonist

Therapeutic targeting and rapid mobilization of endosteal HSC using a small molecule integrin antagonist

The inherent disadvantages of using granulocyte colony-stimulating factor (G-CSF) for hematopoietic stem cell (HSC) mobilization have driven efforts to identify alternate strategies based on single doses of small molecules. Here, we show targeting α9β1/α4β1 integrins with a single dose of a small mo...

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Bibliographic Details
Main Authors: Cao, Benjamin, Zhang, Zhen, Grassinger, Jochen, Williams, Brenda, Heazlewood, Chad K., Churches, Quentin I., James, Simon A., Li, Songhui, Papayannopoulou, Thalia, Nilsson, Susan K.
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4796355/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4796355/

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