Dominant-Negative Effects of Adult-Onset Huntingtin Mutations Alter the Division of Human Embryonic Stem Cells-Derived Neural Cells

Dominant-Negative Effects of Adult-Onset Huntingtin Mutations Alter the Division of Human Embryonic Stem Cells-Derived Neural Cells

Mutations of the huntingtin protein (HTT) gene underlie both adult-onset and juvenile forms of Huntington’s disease (HD). HTT modulates mitotic spindle orientation and cell fate in mouse cortical progenitors from the ventricular zone. Using human embryonic stem cells (hESC) characterized as carrying...

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Bibliographic Details
Main Authors: Lopes, Carla, Aubert, Sophie, Bourgois-Rocha, Fany, Barnat, Monia, Rego, Ana Cristina, Déglon, Nicole, Perrier, Anselme L., Humbert, Sandrine
Format: Online
Language:English
Published: Public Library of Science 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749329/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749329/

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