Disruptions in a cluster of computationally identified enhancers near FOXC1 and GMDS may influence brain development
Regulatory elements are more evolutionarily conserved and provide a larger mutational target than coding regions of the human genome, suggesting that mutations in non-coding regions contribute significantly to development and disease. Using a computational approach to predict gene regulatory enhance...
Main Authors: | Haliburton, Genevieve D. E., McKinsey, Gabriel L., Pollard, Katherine S. |
---|---|
Format: | Online |
Language: | English |
Published: |
Springer Berlin Heidelberg
2015
|
Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4701781/ |
Similar Items
-
Common variants near ABCA1, AFAP1 and GMDS confer risk of primary open-angle glaucoma
by: Gharahkhani, Puya, et al.
Published: (2014) -
Many human accelerated regions are developmental enhancers
by: Capra, John A., et al.
Published: (2013) -
GMDS knockdown impairs cell proliferation and survival in human lung adenocarcinoma
by: Xing Wei, et al.
Published: (2018-05-01) -
Strategies to improve HIV treatment adherence in developed countries: clinical management at the individual level
by: Enriquez, Maithe, et al.
Published: (2011) -
Foxc1 is required by pericytes during fetal brain angiogenesis
by: Siegenthaler, Julie A., et al.
Published: (2013)