Inhibition of FOXC2 restores epithelial phenotype and drug sensitivity in prostate cancer cells with stem-cell properties

Inhibition of FOXC2 restores epithelial phenotype and drug sensitivity in prostate cancer cells with stem-cell properties

Advanced prostate adenocarcinomas enriched in stem-cell features, as well as variant androgen receptor (AR)-negative neuroendocrine (NE)/small-cell prostate cancers are difficult to treat, and account for up to 30% of prostate cancer-related deaths every year. While existing therapies for prostate c...

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Bibliographic Details
Main Authors: Paranjape, A N, Soundararajan, R, Werden, S J, Joseph, R, Taube, J H, Liu, H, Rodriguez-Canales, J, Sphyris, N, Wistuba, I, Miura, N, Dhillon, J, Mahajan, N, Mahajan, K, Chang, J T, Ittmann, M, Maity, S N, Logothetis, C, Tang, D G, Mani, S A
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5116559/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5116559/

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