Antibody induced CD4 down-modulation of T cells is site-specifically mediated by CD64+ cells

Antibody induced CD4 down-modulation of T cells is site-specifically mediated by CD64+ cells

Treatment of PBMC with the CD4-specific mAb BT-061 induces CD4 down-modulation of T cells. Here we report that addition of BT-061 to purified T cells did not confer this effect, whereas incubation of T cells in BT-061 coated wells restored CD4 down-modulation. These results implied that Fcγ receptor...

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Bibliographic Details
Main Authors: Vogel, Stephanie, Grabski, Elena, Buschjäger, Daniela, Klawonn, Frank, Döring, Marius, Wang, Junxi, Fletcher, Erika, Bechmann, Ingo, Witte, Torsten, Durisin, Martin, Schraven, Burkhart, Mangsbo, Sara M., Schönfeld, Kurt, Czeloth, Niklas, Kalinke, Ulrich
Format: Online
Language:English
Published: Nature Publishing Group 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4680940/

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