Signaling Signatures and Functional Properties of Anti-Human CD28 Superagonistic Antibodies
Superagonistic CD28 antibodies (CD28SAs) activate T lymphocytes without concomitant perturbation of the TCR/CD3-complex. In rodents these reagents induce the preferential expansion of regulatory T cells and can be used for the treatment of autoimmune diseases. Unexpectedly, the humanized CD28 supera...
| Main Authors: | , , , , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Public Library of Science
2008
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246163/ |