Selective inhibition of HDAC8 decreases neuroblastoma growth in vitro and in vivo and enhances retinoic acid-mediated differentiation

Selective inhibition of HDAC8 decreases neuroblastoma growth in vitro and in vivo and enhances retinoic acid-mediated differentiation

For differentiation-defective malignancies, compounds that modulate transcription, such as retinoic acid and histone deacetylase (HDAC) inhibitors, are of particular interest. HDAC inhibitors are currently under investigation for the treatment of a broad spectrum of cancer diseases. However, one cli...

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Bibliographic Details
Main Authors: Rettig, I, Koeneke, E, Trippel, F, Mueller, W C, Burhenne, J, Kopp-Schneider, A, Fabian, J, Schober, A, Fernekorn, U, von Deimling, A, Deubzer, H E, Milde, T, Witt, O, Oehme, I
Format: Online
Language:English
Published: Nature Publishing Group 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669789/

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