MYCN and HDAC2 cooperate to repress miR-183 signaling in neuroblastoma

MYCN and HDAC2 cooperate to repress miR-183 signaling in neuroblastoma

MYCN is a master regulator controlling many processes necessary for tumor cell survival. Here, we unravel a microRNA network that causes tumor suppressive effects in MYCN-amplified neuroblastoma cells. In profiling studies, histone deacetylase (HDAC) inhibitor treatment most strongly induced miR-183...

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Bibliographic Details
Main Authors: Lodrini, Marco, Oehme, Ina, Schroeder, Christina, Milde, Till, Schier, Marie C., Kopp-Schneider, Annette, Schulte, Johannes H., Fischer, Matthias, De Preter, Katleen, Pattyn, Filip, Castoldi, Mirco, Muckenthaler, Martina U., Kulozik, Andreas E., Westermann, Frank, Witt, Olaf, Deubzer, Hedwig E.
Format: Online
Language:English
Published: Oxford University Press 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3695529/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3695529/

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