Inhibition of hypoxia inducible factors combined with all-trans retinoic acid treatment enhances glial transdifferentiation of neuroblastoma cells

Inhibition of hypoxia inducible factors combined with all-trans retinoic acid treatment enhances glial transdifferentiation of neuroblastoma cells

Neuroblastoma (NBL) is a heterogeneous tumor characterized by a wide range of clinical manifestations. A high tumor cell differentiation grade correlates to a favorable stage and positive outcome. Expression of the hypoxia inducible factors HIF1-α (HIF1A gene) and HIF2-α (EPAS1 gene) and/or hypoxia-...

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Bibliographic Details
Main Authors: Cimmino, Flora, Pezone, Lucia, Avitabile, Marianna, Acierno, Giovanni, Andolfo, Immacolata, Capasso, Mario, Iolascon, Achille
Format: Online
Language:English
Published: Nature Publishing Group 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4460899/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4460899/

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