Preferential Extracellular Generation of the Active Parkinsonian Toxin MPP+ by Transporter-Independent Export of the Intermediate MPDP+

Preferential Extracellular Generation of the Active Parkinsonian Toxin MPP+ by Transporter-Independent Export of the Intermediate MPDP+

Aims: 1-Methyl-4-phenyl-tetrahydropyridine (MPTP) is among the most widely used neurotoxins for inducing experimental parkinsonism. MPTP causes parkinsonian symptoms in mice, primates, and humans by killing a subpopulation of dopaminergic neurons. Extrapolations of data obtained using MPTP-based par...

Full description

Bibliographic Details
Main Authors: Schildknecht, Stefan, Pape, Regina, Meiser, Johannes, Karreman, Christiaan, Strittmatter, Tobias, Odermatt, Meike, Cirri, Erica, Friemel, Anke, Ringwald, Markus, Pasquarelli, Noemi, Ferger, Boris, Brunner, Thomas, Marx, Andreas, Möller, Heiko M., Hiller, Karsten, Leist, Marcel
Format: Online
Language:English
Published: Mary Ann Liebert, Inc. 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649766/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649766/

Similar Items