The transcriptional landscape of age in human peripheral blood

Disease incidences increase with age, but the molecular characteristics of ageing that lead to increased disease susceptibility remain inadequately understood. Here we perform a whole-blood gene expression meta-analysis in 14,983 individuals of European ancestry (including replication) and identify...

Full description

Bibliographic Details
Main Authors:	Peters, Marjolein J., Joehanes, Roby, Pilling, Luke C., Schurmann, Claudia, Conneely, Karen N., Powell, Joseph, Reinmaa, Eva, Sutphin, George L., Zhernakova, Alexandra, Schramm, Katharina, Wilson, Yana A., Kobes, Sayuko, Tukiainen, Taru, Ramos, Yolande F., Göring, Harald H. H., Fornage, Myriam, Liu, Yongmei, Gharib, Sina A., Stranger, Barbara E., De Jager, Philip L., Aviv, Abraham, Levy, Daniel, Murabito, Joanne M., Munson, Peter J., Huan, Tianxiao, Hofman, Albert, Uitterlinden, André G., Rivadeneira, Fernando, van Rooij, Jeroen, Stolk, Lisette, Broer, Linda, Verbiest, Michael M. P. J., Jhamai, Mila, Arp, Pascal, Metspalu, Andres, Tserel, Liina, Milani, Lili, Samani, Nilesh J., Peterson, Pärt, Kasela, Silva, Codd, Veryan, Peters, Annette, Ward-Caviness, Cavin K., Herder, Christian, Waldenberger, Melanie, Roden, Michael, Singmann, Paula, Zeilinger, Sonja, Illig, Thomas, Homuth, Georg, Grabe, Hans-Jörgen, Völzke, Henry, Steil, Leif, Kocher, Thomas, Murray, Anna, Melzer, David, Yaghootkar, Hanieh, Bandinelli, Stefania, Moses, Eric K., Kent, Jack W., Curran, Joanne E., Johnson, Matthew P., Williams-Blangero, Sarah, Westra, Harm-Jan, McRae, Allan F., Smith, Jennifer A., Kardia, Sharon L. R., Hovatta, Iiris, Perola, Markus, Ripatti, Samuli, Salomaa, Veikko, Henders, Anjali K., Martin, Nicholas G., Smith, Alicia K., Mehta, Divya, Binder, Elisabeth B., Nylocks, K Maria, Kennedy, Elizabeth M., Klengel, Torsten, Ding, Jingzhong, Suchy-Dicey, Astrid M., Enquobahrie, Daniel A., Brody, Jennifer, Rotter, Jerome I., Chen, Yii-Der I., Houwing-Duistermaat, Jeanine, Kloppenburg, Margreet, Slagboom, P. Eline, Helmer, Quinta, den Hollander, Wouter, Bean, Shannon, Raj, Towfique, Bakhshi, Noman, Wang, Qiao Ping, Oyston, Lisa J., Psaty, Bruce M., Tracy, Russell P., Montgomery, Grant W., Turner, Stephen T., Blangero, John, Meulenbelt, Ingrid, Ressler, Kerry J., Yang, Jian, Franke, Lude, Kettunen, Johannes, Visscher, Peter M., Neely, G. Gregory, Korstanje, Ron, Hanson, Robert L., Prokisch, Holger, Ferrucci, Luigi, Esko, Tonu, Teumer, Alexander, van Meurs, Joyce B. J., Johnson, Andrew D.
Format:	Online
Language:	English
Published:	Nature Pub. Group 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4639797/

id	pubmed-4639797
recordtype	oai_dc
spelling	pubmed-46397972015-12-08 The transcriptional landscape of age in human peripheral blood Peters, Marjolein J. Joehanes, Roby Pilling, Luke C. Schurmann, Claudia Conneely, Karen N. Powell, Joseph Reinmaa, Eva Sutphin, George L. Zhernakova, Alexandra Schramm, Katharina Wilson, Yana A. Kobes, Sayuko Tukiainen, Taru Ramos, Yolande F. Göring, Harald H. H. Fornage, Myriam Liu, Yongmei Gharib, Sina A. Stranger, Barbara E. De Jager, Philip L. Aviv, Abraham Levy, Daniel Murabito, Joanne M. Munson, Peter J. Huan, Tianxiao Hofman, Albert Uitterlinden, André G. Rivadeneira, Fernando van Rooij, Jeroen Stolk, Lisette Broer, Linda Verbiest, Michael M. P. J. Jhamai, Mila Arp, Pascal Metspalu, Andres Tserel, Liina Milani, Lili Samani, Nilesh J. Peterson, Pärt Kasela, Silva Codd, Veryan Peters, Annette Ward-Caviness, Cavin K. Herder, Christian Waldenberger, Melanie Roden, Michael Singmann, Paula Zeilinger, Sonja Illig, Thomas Homuth, Georg Grabe, Hans-Jörgen Völzke, Henry Steil, Leif Kocher, Thomas Murray, Anna Melzer, David Yaghootkar, Hanieh Bandinelli, Stefania Moses, Eric K. Kent, Jack W. Curran, Joanne E. Johnson, Matthew P. Williams-Blangero, Sarah Westra, Harm-Jan McRae, Allan F. Smith, Jennifer A. Kardia, Sharon L. R. Hovatta, Iiris Perola, Markus Ripatti, Samuli Salomaa, Veikko Henders, Anjali K. Martin, Nicholas G. Smith, Alicia K. Mehta, Divya Binder, Elisabeth B. Nylocks, K Maria Kennedy, Elizabeth M. Klengel, Torsten Ding, Jingzhong Suchy-Dicey, Astrid M. Enquobahrie, Daniel A. Brody, Jennifer Rotter, Jerome I. Chen, Yii-Der I. Houwing-Duistermaat, Jeanine Kloppenburg, Margreet Slagboom, P. Eline Helmer, Quinta den Hollander, Wouter Bean, Shannon Raj, Towfique Bakhshi, Noman Wang, Qiao Ping Oyston, Lisa J. Psaty, Bruce M. Tracy, Russell P. Montgomery, Grant W. Turner, Stephen T. Blangero, John Meulenbelt, Ingrid Ressler, Kerry J. Yang, Jian Franke, Lude Kettunen, Johannes Visscher, Peter M. Neely, G. Gregory Korstanje, Ron Hanson, Robert L. Prokisch, Holger Ferrucci, Luigi Esko, Tonu Teumer, Alexander van Meurs, Joyce B. J. Johnson, Andrew D. Article Disease incidences increase with age, but the molecular characteristics of ageing that lead to increased disease susceptibility remain inadequately understood. Here we perform a whole-blood gene expression meta-analysis in 14,983 individuals of European ancestry (including replication) and identify 1,497 genes that are differentially expressed with chronological age. The age-associated genes do not harbor more age-associated CpG-methylation sites than other genes, but are instead enriched for the presence of potentially functional CpG-methylation sites in enhancer and insulator regions that associate with both chronological age and gene expression levels. We further used the gene expression profiles to calculate the ‘transcriptomic age' of an individual, and show that differences between transcriptomic age and chronological age are associated with biological features linked to ageing, such as blood pressure, cholesterol levels, fasting glucose, and body mass index. The transcriptomic prediction model adds biological relevance and complements existing epigenetic prediction models, and can be used by others to calculate transcriptomic age in external cohorts. Nature Pub. Group 2015-10-22 /pmc/articles/PMC4639797/ /pubmed/26490707 http://dx.doi.org/10.1038/ncomms9570 Text en Copyright © 2015, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Peters, Marjolein J. Joehanes, Roby Pilling, Luke C. Schurmann, Claudia Conneely, Karen N. Powell, Joseph Reinmaa, Eva Sutphin, George L. Zhernakova, Alexandra Schramm, Katharina Wilson, Yana A. Kobes, Sayuko Tukiainen, Taru Ramos, Yolande F. Göring, Harald H. H. Fornage, Myriam Liu, Yongmei Gharib, Sina A. Stranger, Barbara E. De Jager, Philip L. Aviv, Abraham Levy, Daniel Murabito, Joanne M. Munson, Peter J. Huan, Tianxiao Hofman, Albert Uitterlinden, André G. Rivadeneira, Fernando van Rooij, Jeroen Stolk, Lisette Broer, Linda Verbiest, Michael M. P. J. Jhamai, Mila Arp, Pascal Metspalu, Andres Tserel, Liina Milani, Lili Samani, Nilesh J. Peterson, Pärt Kasela, Silva Codd, Veryan Peters, Annette Ward-Caviness, Cavin K. Herder, Christian Waldenberger, Melanie Roden, Michael Singmann, Paula Zeilinger, Sonja Illig, Thomas Homuth, Georg Grabe, Hans-Jörgen Völzke, Henry Steil, Leif Kocher, Thomas Murray, Anna Melzer, David Yaghootkar, Hanieh Bandinelli, Stefania Moses, Eric K. Kent, Jack W. Curran, Joanne E. Johnson, Matthew P. Williams-Blangero, Sarah Westra, Harm-Jan McRae, Allan F. Smith, Jennifer A. Kardia, Sharon L. R. Hovatta, Iiris Perola, Markus Ripatti, Samuli Salomaa, Veikko Henders, Anjali K. Martin, Nicholas G. Smith, Alicia K. Mehta, Divya Binder, Elisabeth B. Nylocks, K Maria Kennedy, Elizabeth M. Klengel, Torsten Ding, Jingzhong Suchy-Dicey, Astrid M. Enquobahrie, Daniel A. Brody, Jennifer Rotter, Jerome I. Chen, Yii-Der I. Houwing-Duistermaat, Jeanine Kloppenburg, Margreet Slagboom, P. Eline Helmer, Quinta den Hollander, Wouter Bean, Shannon Raj, Towfique Bakhshi, Noman Wang, Qiao Ping Oyston, Lisa J. Psaty, Bruce M. Tracy, Russell P. Montgomery, Grant W. Turner, Stephen T. Blangero, John Meulenbelt, Ingrid Ressler, Kerry J. Yang, Jian Franke, Lude Kettunen, Johannes Visscher, Peter M. Neely, G. Gregory Korstanje, Ron Hanson, Robert L. Prokisch, Holger Ferrucci, Luigi Esko, Tonu Teumer, Alexander van Meurs, Joyce B. J. Johnson, Andrew D.
spellingShingle	Peters, Marjolein J. Joehanes, Roby Pilling, Luke C. Schurmann, Claudia Conneely, Karen N. Powell, Joseph Reinmaa, Eva Sutphin, George L. Zhernakova, Alexandra Schramm, Katharina Wilson, Yana A. Kobes, Sayuko Tukiainen, Taru Ramos, Yolande F. Göring, Harald H. H. Fornage, Myriam Liu, Yongmei Gharib, Sina A. Stranger, Barbara E. De Jager, Philip L. Aviv, Abraham Levy, Daniel Murabito, Joanne M. Munson, Peter J. Huan, Tianxiao Hofman, Albert Uitterlinden, André G. Rivadeneira, Fernando van Rooij, Jeroen Stolk, Lisette Broer, Linda Verbiest, Michael M. P. J. Jhamai, Mila Arp, Pascal Metspalu, Andres Tserel, Liina Milani, Lili Samani, Nilesh J. Peterson, Pärt Kasela, Silva Codd, Veryan Peters, Annette Ward-Caviness, Cavin K. Herder, Christian Waldenberger, Melanie Roden, Michael Singmann, Paula Zeilinger, Sonja Illig, Thomas Homuth, Georg Grabe, Hans-Jörgen Völzke, Henry Steil, Leif Kocher, Thomas Murray, Anna Melzer, David Yaghootkar, Hanieh Bandinelli, Stefania Moses, Eric K. Kent, Jack W. Curran, Joanne E. Johnson, Matthew P. Williams-Blangero, Sarah Westra, Harm-Jan McRae, Allan F. Smith, Jennifer A. Kardia, Sharon L. R. Hovatta, Iiris Perola, Markus Ripatti, Samuli Salomaa, Veikko Henders, Anjali K. Martin, Nicholas G. Smith, Alicia K. Mehta, Divya Binder, Elisabeth B. Nylocks, K Maria Kennedy, Elizabeth M. Klengel, Torsten Ding, Jingzhong Suchy-Dicey, Astrid M. Enquobahrie, Daniel A. Brody, Jennifer Rotter, Jerome I. Chen, Yii-Der I. Houwing-Duistermaat, Jeanine Kloppenburg, Margreet Slagboom, P. Eline Helmer, Quinta den Hollander, Wouter Bean, Shannon Raj, Towfique Bakhshi, Noman Wang, Qiao Ping Oyston, Lisa J. Psaty, Bruce M. Tracy, Russell P. Montgomery, Grant W. Turner, Stephen T. Blangero, John Meulenbelt, Ingrid Ressler, Kerry J. Yang, Jian Franke, Lude Kettunen, Johannes Visscher, Peter M. Neely, G. Gregory Korstanje, Ron Hanson, Robert L. Prokisch, Holger Ferrucci, Luigi Esko, Tonu Teumer, Alexander van Meurs, Joyce B. J. Johnson, Andrew D. The transcriptional landscape of age in human peripheral blood
author_facet	Peters, Marjolein J. Joehanes, Roby Pilling, Luke C. Schurmann, Claudia Conneely, Karen N. Powell, Joseph Reinmaa, Eva Sutphin, George L. Zhernakova, Alexandra Schramm, Katharina Wilson, Yana A. Kobes, Sayuko Tukiainen, Taru Ramos, Yolande F. Göring, Harald H. H. Fornage, Myriam Liu, Yongmei Gharib, Sina A. Stranger, Barbara E. De Jager, Philip L. Aviv, Abraham Levy, Daniel Murabito, Joanne M. Munson, Peter J. Huan, Tianxiao Hofman, Albert Uitterlinden, André G. Rivadeneira, Fernando van Rooij, Jeroen Stolk, Lisette Broer, Linda Verbiest, Michael M. P. J. Jhamai, Mila Arp, Pascal Metspalu, Andres Tserel, Liina Milani, Lili Samani, Nilesh J. Peterson, Pärt Kasela, Silva Codd, Veryan Peters, Annette Ward-Caviness, Cavin K. Herder, Christian Waldenberger, Melanie Roden, Michael Singmann, Paula Zeilinger, Sonja Illig, Thomas Homuth, Georg Grabe, Hans-Jörgen Völzke, Henry Steil, Leif Kocher, Thomas Murray, Anna Melzer, David Yaghootkar, Hanieh Bandinelli, Stefania Moses, Eric K. Kent, Jack W. Curran, Joanne E. Johnson, Matthew P. Williams-Blangero, Sarah Westra, Harm-Jan McRae, Allan F. Smith, Jennifer A. Kardia, Sharon L. R. Hovatta, Iiris Perola, Markus Ripatti, Samuli Salomaa, Veikko Henders, Anjali K. Martin, Nicholas G. Smith, Alicia K. Mehta, Divya Binder, Elisabeth B. Nylocks, K Maria Kennedy, Elizabeth M. Klengel, Torsten Ding, Jingzhong Suchy-Dicey, Astrid M. Enquobahrie, Daniel A. Brody, Jennifer Rotter, Jerome I. Chen, Yii-Der I. Houwing-Duistermaat, Jeanine Kloppenburg, Margreet Slagboom, P. Eline Helmer, Quinta den Hollander, Wouter Bean, Shannon Raj, Towfique Bakhshi, Noman Wang, Qiao Ping Oyston, Lisa J. Psaty, Bruce M. Tracy, Russell P. Montgomery, Grant W. Turner, Stephen T. Blangero, John Meulenbelt, Ingrid Ressler, Kerry J. Yang, Jian Franke, Lude Kettunen, Johannes Visscher, Peter M. Neely, G. Gregory Korstanje, Ron Hanson, Robert L. Prokisch, Holger Ferrucci, Luigi Esko, Tonu Teumer, Alexander van Meurs, Joyce B. J. Johnson, Andrew D.
author_sort	Peters, Marjolein J.
title	The transcriptional landscape of age in human peripheral blood
title_short	The transcriptional landscape of age in human peripheral blood
title_full	The transcriptional landscape of age in human peripheral blood
title_fullStr	The transcriptional landscape of age in human peripheral blood
title_full_unstemmed	The transcriptional landscape of age in human peripheral blood
title_sort	transcriptional landscape of age in human peripheral blood
description	Disease incidences increase with age, but the molecular characteristics of ageing that lead to increased disease susceptibility remain inadequately understood. Here we perform a whole-blood gene expression meta-analysis in 14,983 individuals of European ancestry (including replication) and identify 1,497 genes that are differentially expressed with chronological age. The age-associated genes do not harbor more age-associated CpG-methylation sites than other genes, but are instead enriched for the presence of potentially functional CpG-methylation sites in enhancer and insulator regions that associate with both chronological age and gene expression levels. We further used the gene expression profiles to calculate the ‘transcriptomic age' of an individual, and show that differences between transcriptomic age and chronological age are associated with biological features linked to ageing, such as blood pressure, cholesterol levels, fasting glucose, and body mass index. The transcriptomic prediction model adds biological relevance and complements existing epigenetic prediction models, and can be used by others to calculate transcriptomic age in external cohorts.
publisher	Nature Pub. Group
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4639797/
_version_	1613499417671761920

The transcriptional landscape of age in human peripheral blood

Similar Items