Carbonic anhydrase IX induction defines a heterogeneous cancer cell response to hypoxia and mediates stem cell-like properties and sensitivity to HDAC inhibition

Carbonic anhydrase IX induction defines a heterogeneous cancer cell response to hypoxia and mediates stem cell-like properties and sensitivity to HDAC inhibition

Carbonic anhydrase IX (CAIX) is strongly induced by hypoxia and its overexpression is associated with poor therapeutic outcome in cancer. Here, we report that hypoxia promotes tumour heterogeneity through the epigenetic regulation of CAIX. Based on hypoxic CAIX expression we identify and characteriz...

Full description

Bibliographic Details
Main Authors:	Ledaki, Ioanna, McIntyre, Alan, Wigfield, Simon, Buffa, Francesca, McGowan, Simon, Baban, Dilair, Li, Ji-liang, Harris, Adrian L.
Format:	Online
Language:	English
Published:	Impact Journals LLC 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637295/

Similar Items

Hypoxia-induced carbonic anhydrase IX facilitates lactate flux in human breast cancer cells by non-catalytic function
by: Jamali, Somayeh, et al.
Published: (2015)

Knock-down of hypoxia-induced carbonic anhydrases IX and XII radiosensitizes tumor cells by increasing intracellular acidosis
by: Doyen, Jérome, et al.
Published: (2013)

Cyclooxygenase-2/carbonic anhydrase-IX up-regulation promotes invasive potential and hypoxia survival in colorectal cancer cells
by: Sansone, Pasquale, et al.
Published: (2009)

Carbonic anhydrase IX in oligodendroglial brain tumors
by: Järvelä, Sally, et al.
Published: (2008)

Methyl Sulfone Blocked Multiple Hypoxia- and Non-Hypoxia-Induced Metastatic Targets in Breast Cancer Cells and Melanoma Cells
by: Caron, Joan McIntyre, et al.
Published: (2015)

The effect of carbonic anhydrase IX on focal contacts during cell spreading and migration
by: Csaderova, Lucia, et al.
Published: (2013)

Recent Developments in Targeting Carbonic Anhydrase IX for Cancer Therapeutics
by: McDonald, Paul C., et al.
Published: (2012)

Structural Insights into Carbonic Anhydrase IX Isoform Specificity of Carbohydrate-Based Sulfamates
by: Moeker, Janina, et al.
Published: (2014)

In Vivo Imaging and Quantification of Carbonic Anhydrase IX Expression as an Endogenous Biomarker of Tumor Hypoxia
by: Bao, Bagna, et al.
Published: (2012)

Carbonic anhydrase IX, a hypoxia-induced catalytic component of the pH regulating machinery in tumors
by: Sedlakova, Olga, et al.
Published: (2014)

Carbonic anhydrase IX is a marker of hypoxia and correlates with higher Gleason scores and ISUP grading in prostate cancer
by: Ambrosio, Maria Raffaella, et al.
Published: (2016)

Genomic alterations underlie a pan-cancer metabolic shift associated with tumour hypoxia
by: Haider, Syed, et al.
Published: (2016)

Expression of carbonic anhydrase IX suggests poor response to therapy in rectal cancer
by: Span, P N, et al.
Published: (2009)

Expression of carbonic anhydrases IX and XII during mouse embryonic development
by: Kallio, Heini, et al.
Published: (2006)

Optimization of a Novel Peptide Ligand Targeting Human Carbonic Anhydrase IX
by: Rana, Shoaib, et al.
Published: (2012)

Transmembrane carbonic anhydrase isozymes IX and XII in the female mouse reproductive organs
by: Hynninen, Piritta, et al.
Published: (2004)

Carbonic anhydrase enzymes II, VII, IX and XII in colorectal carcinomas
by: Viikilä, Pia, et al.
Published: (2016)

Imaging of carbonic anhydrase IX with an 111In-labeled dual-motif inhibitor
by: Yang, Xing, et al.
Published: (2015)

Circulating Carbonic Anhydrase IX and Antiangiogenic Therapy in Breast Cancer
by: Brown-Glaberman, Ursa, et al.
Published: (2016)

Apoptosis-induced ectodomain shedding of hypoxia-regulated carbonic anhydrase IX from tumor cells: a double-edged response to chemotherapy
by: Vidlickova, Ivana, et al.
Published: (2016)

The BET inhibitor JQ1 selectively impairs tumour response to hypoxia and downregulates CA9 and angiogenesis in triple negative breast cancer
by: da Motta, L L, et al.
Published: (2017)

Binding of the Phage Display Derived Peptide CaIX-P1 on Human Colorectal Carcinoma Cells Correlates with the Expression of Carbonic Anhydrase IX
by: Askoxylakis, Vasileios, et al.
Published: (2012)

Prognostic Significance of Carbonic Anhydrase IX Expression in Cancer Patients: A Meta-Analysis
by: van Kuijk, Simon J. A., et al.
Published: (2016)

The prognostic impact of a combined carbonic anhydrase IX and Ki67 signature in oral squamous cell carcinoma
by: Klimowicz, A C, et al.
Published: (2013)

Identifying the stromal cell type that contributes to tumor aggressiveness associated with carbonic anhydrase IX
by: Bose, Pinaki, et al.
Published: (2013)

Prognostic utility of pre-operative circulating osteopontin, carbonic anhydrase IX and CRP in renal cell carcinoma
by: Sim, S H, et al.
Published: (2012)

Application of Monoclonal Antibody G250 Recognizing Carbonic Anhydrase IX in Renal Cell Carcinoma
by: Oosterwijk-Wakka, Jeannette C., et al.
Published: (2013)

Prognostic value of serum carbonic anhydrase IX in testicular germ cell tumor patients
by: Kalavska, Katarina, et al.
Published: (2016)

Prognostic Value of Carbonic Anhydrase IX Immunohistochemical Expression in Renal Cell Carcinoma: A Meta-Analysis of the Literature
by: Zhao, Zhihong, et al.
Published: (2014)

The Potential of Liposomes with Carbonic Anhydrase IX to Deliver Anticancer Ingredients to Cancer Cells in Vivo
by: Ng, Huei Leng Helena, et al.
Published: (2014)

Carbonic anhydrase IX-directed immunoliposomes for targeted drug delivery to human lung cancer cells in vitro
by: Wong, Blenda Chi Kwan, et al.
Published: (2014)

Binding of Carbonic Anhydrase IX to 45S rDNA Genes Is Prevented by Exportin-1 in Hypoxic Cells
by: Sasso, Emanuele, et al.
Published: (2015)

The Role of Hypoxia-Inducible Factor-1α, Glucose Transporter-1, (GLUT-1) and Carbon Anhydrase IX in Endometrial Cancer Patients
by: Sadlecki, Pawel, et al.
Published: (2014)

Peroxisome Proliferator Activated Receptor-α/Hypoxia Inducible Factor-1α Interplay Sustains Carbonic Anhydrase IX and Apoliprotein E Expression in Breast Cancer Stem Cells
by: Papi, Alessio, et al.
Published: (2013)

Gene expression and hypoxia in breast cancer
by: Favaro, Elena, et al.
Published: (2011)

Reply: expression of carbonic anhydrase IX suggests poor response to therapy in rectal cancer
by: Korkeila, E, et al.
Published: (2009)

Downregulation of Carbonic Anhydrase IX Promotes Col10a1 Expression in Chondrocytes
by: Maruyama, Toshifumi, et al.
Published: (2013)

Histopathological Determinants of Tumor Resistance: A Special Look to the Immunohistochemical Expression of Carbonic Anhydrase IX in Human Cancers
by: Ilardi, G., et al.
Published: (2014)

Carnosine inhibits carbonic anhydrase IX-mediated extracellular acidosis and suppresses growth of HeLa tumor xenografts
by: Ditte, Zuzana, et al.
Published: (2014)

Expression of carbonic anhydrase IX in human fetal joints, ligaments and tendons: a potential marker of mechanical stress in fetal development?
by: Kim, Ji Hyun, et al.
Published: (2013)