Carbonic anhydrase IX induction defines a heterogeneous cancer cell response to hypoxia and mediates stem cell-like properties and sensitivity to HDAC inhibition

Carbonic anhydrase IX induction defines a heterogeneous cancer cell response to hypoxia and mediates stem cell-like properties and sensitivity to HDAC inhibition

Carbonic anhydrase IX (CAIX) is strongly induced by hypoxia and its overexpression is associated with poor therapeutic outcome in cancer. Here, we report that hypoxia promotes tumour heterogeneity through the epigenetic regulation of CAIX. Based on hypoxic CAIX expression we identify and characteriz...

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Bibliographic Details
Main Authors: Ledaki, Ioanna, McIntyre, Alan, Wigfield, Simon, Buffa, Francesca, McGowan, Simon, Baban, Dilair, Li, Ji-liang, Harris, Adrian L.
Format: Online
Language:English
Published: Impact Journals LLC 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637295/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637295/

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