Inhibition of the Aurora A kinase augments the anti-tumor efficacy of oncolytic measles virotherapy

Inhibition of the Aurora A kinase augments the anti-tumor efficacy of oncolytic measles virotherapy

Oncolytic measles virus (MV) strains have demonstrated broad spectrum preclinical anti-tumor, including breast cancer. Aurora A kinase controls mitotic spindle formation and plays a critical role in malignant transformation. We hypothesized that, by causing mitotic arrest, the Aurora A kinase inhibi...

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Bibliographic Details
Main Authors: Iankov, Ianko D., Kurokawa, Cheyne B., D’Assoro, Antonio B., Ingle, James N., Domingo-Musibay, Evidio, Allen, Cory, Crosby, Catherine M., Nair, Asha A., Liu, Minetta C., Aderca, Ileana, Federspiel, Mark J., Galanis, Evanthia
Format: Online
Language:English
Published: 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589445/

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