MicroRNA-Detargeted Mengovirus for Oncolytic Virotherapy
Mengovirus, a member of the Picornaviridae family, has a broad cell tropism and can cause encephalitis and myocarditis in multiple mammalian species. Attenuation has been achieved by shortening the polycytidine tract in the 5′ noncoding region (NCR). A poly(C)-truncated strain of mengovirus, vMC24,...
| Main Authors: | , , , |
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| Format: | Online |
| Language: | English |
| Published: |
American Society for Microbiology
2016
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810567/ |