Gene Expression Ratios Lead to Accurate and Translatable Predictors of DR5 Agonism across Multiple Tumor Lineages

Gene Expression Ratios Lead to Accurate and Translatable Predictors of DR5 Agonism across Multiple Tumor Lineages

Death Receptor 5 (DR5) agonists demonstrate anti-tumor activity in preclinical models but have yet to demonstrate robust clinical responses. A key limitation may be the lack of patient selection strategies to identify those most likely to respond to treatment. To overcome this limitation, we screene...

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Bibliographic Details
Main Authors: Reddy, Anupama, Growney, Joseph D., Wilson, Nick S., Emery, Caroline M., Johnson, Jennifer A., Ward, Rebecca, Monaco, Kelli A., Korn, Joshua, Monahan, John E., Stump, Mark D., Mapa, Felipa A., Wilson, Christopher J., Steiger, Janine, Ledell, Jebediah, Rickles, Richard J., Myer, Vic E., Ettenberg, Seth A., Schlegel, Robert, Sellers, William R., Huet, Heather A., Lehár, Joseph
Format: Online
Language:English
Published: Public Library of Science 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4574744/

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