Biased agonism in drug discovery: is it too soon to choose a path?
A single receptor can activate multiple signaling pathways that have distinct or even opposite effects on cell function. Biased agonists stabilize receptor conformations preferentially stimulating one of these pathways, and therefore allow a more targeted modulation of cell function and treatment of...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
American Society for Pharmacology and Experimental Therapeutics
2018
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| Online Access: | http://eprints.nottingham.ac.uk/50607/ http://eprints.nottingham.ac.uk/50607/ http://eprints.nottingham.ac.uk/50607/ http://eprints.nottingham.ac.uk/50607/1/biased%20MP.pdf |