Inhibition of indoleamine 2,3-dioxygenase 1 expression alters immune response in colon tumor microenvironment in mice

Inhibition of indoleamine 2,3-dioxygenase 1 expression alters immune response in colon tumor microenvironment in mice

Indoleamine 2,3-dioxygenase (IDO), an enzyme that degrades the essential amino acid l-tryptophan along the kynurenine pathway, exerts immunomodulatory effects in a number of diseases. IDO expression is increased in tumor tissue and in draining lymph nodes; this increase is thought to play a role in...

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Bibliographic Details
Main Authors: Takamatsu, Manabu, Hirata, Akihiro, Ohtaki, Hirofumi, Hoshi, Masato, Ando, Tatsuya, Ito, Hiroyasu, Hatano, Yuichiro, Tomita, Hiroyuki, Kuno, Toshiya, Saito, Kuniaki, Seishima, Mitsuru, Hara, Akira
Format: Online
Language:English
Published: John Wiley & Sons, Ltd 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556390/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556390/

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