Subacute calorie restriction and rapamycin discordantly alter mouse liver proteome homeostasis and reverse aging effects

Subacute calorie restriction and rapamycin discordantly alter mouse liver proteome homeostasis and reverse aging effects

Calorie restriction (CR) and rapamycin (RP) extend lifespan and improve health across model organisms. Both treatments inhibit mammalian target of rapamycin (mTOR) signaling, a conserved longevity pathway and a key regulator of protein homeostasis, yet their effects on proteome homeostasis are relat...

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Bibliographic Details
Main Authors: Karunadharma, Pabalu P, Basisty, Nathan, Dai, Dao-Fu, Chiao, Ying A, Quarles, Ellen K, Hsieh, Edward J, Crispin, David, Bielas, Jason H, Ericson, Nolan G, Beyer, Richard P, MacKay, Vivian L, MacCoss, Michael J, Rabinovitch, Peter S
Format: Online
Language:English
Published: John Wiley & Sons, Ltd 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531069/

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