Altered proteome turnover and remodeling by short-term caloric restriction or rapamycin rejuvenate the aging heart

Altered proteome turnover and remodeling by short-term caloric restriction or rapamycin rejuvenate the aging heart

Chronic caloric restriction (CR) and rapamycin inhibit the mechanistic target of rapamycin (mTOR) signaling, thereby regulating metabolism and suppressing protein synthesis. Caloric restriction or rapamycin extends murine lifespan and ameliorates many aging-associated disorders; however, the benefic...

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Bibliographic Details
Main Authors: Dai, Dao-Fu, Karunadharma, Pabalu P, Chiao, Ying A, Basisty, Nathan, Crispin, David, Hsieh, Edward J, Chen, Tony, Gu, Haiwei, Djukovic, Danijel, Raftery, Daniel, Beyer, Richard P, MacCoss, Michael J, Rabinovitch, Peter S
Format: Online
Language:English
Published: BlackWell Publishing Ltd 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4040127/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4040127/

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