Using BRAFV600E as a marker of autophagy dependence in pediatric brain tumors
Autophagy inhibition is a potential therapeutic strategy in central nervous system (CNS) tumors. The BRAFV600E mutation is known to affect autophagy. Our studies indicate CNS tumor cells with BRAFV600E mutant cells (but not wild type) display high rates of induced autophagy, are sensitive to autopha...
| Main Authors: | , , |
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| Format: | Online |
| Language: | English |
| Published: |
Taylor & Francis
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502777/ |