BRAFV600E inhibition stimulates AMP-activated protein kinase-mediated autophagy in colorectal cancer cells

BRAFV600E inhibition stimulates AMP-activated protein kinase-mediated autophagy in colorectal cancer cells

Although BRAFV600E mutation is associated with adverse clinical outcomes in patients with colorectal cancer (CRC), response and resistance mechanisms for therapeutic BRAFV600E inhibitors remains poorly understood. In the present study, we demonstrate that selective BRAFV600E inhibition activates AMP...

Full description

Bibliographic Details
Main Authors: Sueda, Toshinori, Sakai, Daisuke, Kawamoto, Koichi, Konno, Masamitsu, Nishida, Naohiro, Koseki, Jun, Colvin, Hugh, Takahashi, Hidekazu, Haraguchi, Naotsugu, Nishimura, Junichi, Hata, Taishi, Takemasa, Ichiro, Mizushima, Tsunekazu, Yamamoto, Hirofumi, Satoh, Taroh, Doki, Yuichiro, Mori, Masaki, Ishii, Hideshi
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4707439/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4707439/

Similar Items