TRPM7 maintains progenitor-like features of neuroblastoma cells: implications for metastasis formation

Neuroblastoma is an embryonal tumor derived from poorly differentiated neural crest cells. Current research is aimed at identifying the molecular mechanisms that maintain the progenitor state of neuroblastoma cells and to develop novel therapeutic strategies that induce neuroblastoma cell differenti...

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Main Authors:	Middelbeek, Jeroen, Visser, Daan, Henneman, Linda, Kamermans, Alwin, Kuipers, Arthur J., Hoogerbrugge, Peter M., Jalink, Kees, van Leeuwen, Frank N.
Format:	Online
Language:	English
Published:	Impact Journals LLC 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496182/

id	pubmed-4496182
recordtype	oai_dc
spelling	pubmed-44961822015-07-10 TRPM7 maintains progenitor-like features of neuroblastoma cells: implications for metastasis formation Middelbeek, Jeroen Visser, Daan Henneman, Linda Kamermans, Alwin Kuipers, Arthur J. Hoogerbrugge, Peter M. Jalink, Kees van Leeuwen, Frank N. Research Paper Neuroblastoma is an embryonal tumor derived from poorly differentiated neural crest cells. Current research is aimed at identifying the molecular mechanisms that maintain the progenitor state of neuroblastoma cells and to develop novel therapeutic strategies that induce neuroblastoma cell differentiation. Mechanisms controlling neural crest development are typically dysregulated during neuroblastoma progression, and provide an appealing starting point for drug target discovery. Impact Journals LLC 2015-03-05 /pmc/articles/PMC4496182/ /pubmed/25797249 Text en Copyright: © 2015 Middelbeek et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Middelbeek, Jeroen Visser, Daan Henneman, Linda Kamermans, Alwin Kuipers, Arthur J. Hoogerbrugge, Peter M. Jalink, Kees van Leeuwen, Frank N.
spellingShingle	Middelbeek, Jeroen Visser, Daan Henneman, Linda Kamermans, Alwin Kuipers, Arthur J. Hoogerbrugge, Peter M. Jalink, Kees van Leeuwen, Frank N. TRPM7 maintains progenitor-like features of neuroblastoma cells: implications for metastasis formation
author_facet	Middelbeek, Jeroen Visser, Daan Henneman, Linda Kamermans, Alwin Kuipers, Arthur J. Hoogerbrugge, Peter M. Jalink, Kees van Leeuwen, Frank N.
author_sort	Middelbeek, Jeroen
title	TRPM7 maintains progenitor-like features of neuroblastoma cells: implications for metastasis formation
title_short	TRPM7 maintains progenitor-like features of neuroblastoma cells: implications for metastasis formation
title_full	TRPM7 maintains progenitor-like features of neuroblastoma cells: implications for metastasis formation
title_fullStr	TRPM7 maintains progenitor-like features of neuroblastoma cells: implications for metastasis formation
title_full_unstemmed	TRPM7 maintains progenitor-like features of neuroblastoma cells: implications for metastasis formation
title_sort	trpm7 maintains progenitor-like features of neuroblastoma cells: implications for metastasis formation
description	Neuroblastoma is an embryonal tumor derived from poorly differentiated neural crest cells. Current research is aimed at identifying the molecular mechanisms that maintain the progenitor state of neuroblastoma cells and to develop novel therapeutic strategies that induce neuroblastoma cell differentiation. Mechanisms controlling neural crest development are typically dysregulated during neuroblastoma progression, and provide an appealing starting point for drug target discovery.
publisher	Impact Journals LLC
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496182/
_version_	1613245787122171904

TRPM7 maintains progenitor-like features of neuroblastoma cells: implications for metastasis formation

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